公开(公告)号：US08951739B2

公开(公告)日：2015-02-10

申请号：US13389903

申请日：2010-08-12

申请人： Noriyuki Kawamura ,  Kosaku Shinoda ,  Yoshiaki Ohashi ,  Takamasa Ishikawa ,  Hajime Sato

发明人： Noriyuki Kawamura ,  Kosaku Shinoda ,  Yoshiaki Ohashi ,  Takamasa Ishikawa ,  Hajime Sato

IPC分类号： G01N33/53 ,  G01N33/68

CPC分类号： G01N33/6893 ,  G01N33/92 ,  G01N2800/304 ,  G01N2800/52 ,  Y10T436/163333

摘要： Provided is a method for using low molecular weight compounds found in the body as a biomarker for diagnosing depression. Specifically, more than one compound selected from a group comprising the following are used: ADP-ribose, ATP, ADP, AMP, serotonin, tryptophan, kynurenine, SDMA (symmetrical dimethylarginine), threonine, glyceric acid, serine, N-acetylaspartic acid, glutamic acid, trigonelline, creatine, 2-methylserine, sphingosine, homovanillic acid, piperidine, sulfoxidized methionine, pipecolic acid, sphinganine, gamma-butyrobetaine, guanidinoacetic acid, isobutyric acid, creatinine, sarcosine, 3-methylbutyric acid, nicotinamide, betaine, ornithine, carnitine, ethanolamine, phosphoethanolamine, taurine, hypotaurine, aspartic acid, methionine, and tyrosine.

摘要翻译： 提供了一种使用体内发现的低分子化合物作为诊断抑郁症的生物标志物的方法。 具体地说，使用选自以下的多种化合物：ADP-核糖，ATP，ADP，AMP，5-羟色胺，色氨酸，犬尿胆碱，SDMA（对称二甲基精氨酸），苏氨酸，甘油酸，丝氨酸，N-乙酰天冬氨酸， 谷氨酸，葫芦巴碱，肌酸，2-甲基丝氨酸，鞘氨醇，高香草酸，哌啶，亚砜化甲硫氨酸，哌可酸，二氢鞘氨酸，γ-丁基甜菜碱，胍基乙酸，异丁酸，肌氨酸，肌氨酸，3-甲基丁酸，烟酰胺，甜菜碱，鸟氨酸 肉碱，乙醇胺，磷酸乙醇胺，牛磺酸，牛磺酸，天门冬氨酸，甲硫氨酸和酪氨酸。

公开(公告)号：US20120282592A1

公开(公告)日：2012-11-08

申请号：US13389903

申请日：2010-08-12

申请人： Noriyuki Kawamura ,  Kosaku Shinoda ,  Yoshiaki Ohashi ,  Takamasa Ishikawa ,  Hajime Sato

发明人： Noriyuki Kawamura ,  Kosaku Shinoda ,  Yoshiaki Ohashi ,  Takamasa Ishikawa ,  Hajime Sato

IPC分类号： G01N33/50 ,  G01N33/53 ,  G01N27/447 ,  C12Q1/00

CPC分类号： G01N33/6893 ,  G01N33/92 ,  G01N2800/304 ,  G01N2800/52 ,  Y10T436/163333

摘要： Provided is a method for using low molecular weight compounds found in the body as a biomarker for diagnosing depression. Specifically, more than one compound selected from a group comprising the following are used: ADP-ribose, ATP, ADP, AMP, serotonin, tryptophan, kynurenine, SDMA (symmetrical dimethylarginine), threonine, glyceric acid, serine, N-acetylaspartic acid, glutamic acid, trigonelline, creatine, 2-methylserine, sphingosine, homovanillic acid, piperidine, sulfoxidized methionine, pipecolic acid, sphinganine, gamma-butyrobetaine, guanidinoacetic acid, isobutyric acid, creatinine, sarcosine, 3-methylbutyric acid, nicotinamide, betaine, ornithine, carnitine, ethanolamine, phosphoethanolamine, taurine, hypotaurine, aspartic acid, methionine, and tyrosine.

摘要翻译： 提供了一种使用体内发现的低分子化合物作为诊断抑郁症的生物标志物的方法。 具体地说，使用选自以下的多种化合物：ADP-核糖，ATP，ADP，AMP，5-羟色胺，色氨酸，犬尿胆碱，SDMA（对称二甲基精氨酸），苏氨酸，甘油酸，丝氨酸，N-乙酰天冬氨酸， 谷氨酸，葫芦巴碱，肌酸，2-甲基丝氨酸，鞘氨醇，高香草酸，哌啶，亚砜化甲硫氨酸，哌可酸，二氢鞘氨酸，γ-丁基甜菜碱，胍基乙酸，异丁酸，肌氨酸，肌氨酸，3-甲基丁酸，烟酰胺，甜菜碱，鸟氨酸 肉碱，乙醇胺，磷酸乙醇胺，牛磺酸，牛磺酸，天门冬氨酸，甲硫氨酸和酪氨酸。

公开(公告)号：US4563715A

公开(公告)日：1986-01-07

申请号：US457487

申请日：1983-01-12

申请人： Noriyuki Kawamura ,  Nobuhiro Aizawa ,  Shigeki Koizumi ,  Masaru Koyahara ,  Tetsuo Tomita

发明人： Noriyuki Kawamura ,  Nobuhiro Aizawa ,  Shigeki Koizumi ,  Masaru Koyahara ,  Tetsuo Tomita

IPC分类号： G11B27/10 ,  G11B5/48 ,  G11B5/55 ,  G11B21/08

CPC分类号： G11B5/4886 ,  G11B5/5547

摘要： A head position control device capable of controlling the position of mutually cooperating plural heads with a circuit provided in a drive thereby reducing the burden of the attached system and enabling independent seeking operations of the heads on a magnetic disk. The head position control device of the present invention performs track seeking operation within a minimum time regardless of the access time of the attached system thereby reducing the head switching time, and also allows reduction in the dimension and weight of the entire system.

摘要翻译： 一种头位置控制装置，其能够利用设置在驱动器中的电路来控制相互协作的多个头部的位置，从而减少附接系统的负担，并使得磁头在磁盘上的独立的寻道操作。 本发明的头位置控制装置不管连接系统的访问时间如何，在最小时间内执行追踪操作，从而降低了头切换时间，并且还减少了整个系统的尺寸和重量。

公开(公告)号：US4742409A

公开(公告)日：1988-05-03

申请号：US914541

申请日：1986-10-01

申请人： Masaru Koyahara ,  Shigeki Koizumi ,  Nobuhiro Aisawa ,  Tetsuo Tomita ,  Noriyuki Kawamura

发明人： Masaru Koyahara ,  Shigeki Koizumi ,  Nobuhiro Aisawa ,  Tetsuo Tomita ,  Noriyuki Kawamura

IPC分类号： G11B5/54 ,  G11B17/028 ,  G11B17/04

CPC分类号： G11B17/043 ,  G11B17/0284 ,  G11B5/54

摘要： A magnetic disc unit comprising motor means having a spindle rotatably mounted on a base for rotating a magnetic recording medium, a loading arm having one end swingably attached to the base and a center cone rotatably attached to the other end of the loading arm. The magnetic recording medium is interposed between the spindle and the center cone. A button lever having a control button projecting from one end is attached to the base and is movable with respect thereto. A clamping lever is also mounted to the base and linkage means interlocks the control button and the clamping lever. Depression of the control button translates the button lever so as to rotate the clamping lever to a first position in which the center cone engages the spindle with the magnetic recording medium interposed therebetween. Further depression of the control button translates the button lever to rotate the loading arm to a second position in which the center cone is released from the magnetic recording medium and the clamping lever presses the loading arm in the vicinity of the center cone.

摘要翻译： 一种磁盘单元，包括具有可旋转地安装在用于旋转磁记录介质的基座上的主轴的电动机装置，具有可摆动地附接到基座的一端的装载臂和可旋转地附接到装载臂的另一端的中心锥体。 磁记录介质介于主轴和中心锥体之间。 具有从一端突出的控制按钮的按钮杠杆附接到基座并且可相对于其移动。 夹紧杆也安装在基座上，联动装置联锁控制按钮和夹紧杆。 控制按钮的凹陷使按钮杆转动，以将夹紧杆旋转到第一位置，在第一位置中，中心锥体与主轴接合，并且介于其间的磁记录介质。 控制按钮的进一步按压使按钮杆转动以使装载臂旋转到第二位置，在第二位置中，中心锥从磁记录介质中释放，夹紧杆将装载臂压在中心锥体附近。