公开(公告)号：US20190177324A1

公开(公告)日：2019-06-13

申请号：US16323668

申请日：2017-09-28

Applicant: Novartis AG

Inventor： Anthony CASAREZ ,  Markus FUREGATI ,  Guido KOCH ,  Xiaodong LIN ,  Flavio OSSOLA ,  Folkert RECK ,  Robert Lowell SIMMONS ,  Qingming ZHU

IPC: C07D471/18 ,  A61P31/04 ,  A61K31/439 ,  A61K31/4545 ,  A61K31/427 ,  A61K31/546 ,  A61K31/407 ,  A61K31/496

Abstract: This invention pertains generally to compounds of Formula (A), as further described herein, which act as beta-lactamase inhibitors, and salts, crystalline forms and formulations thereof. In certain aspects, the invention pertains to methods of using such compounds in combination with a beta-lactam antibiotic to treat infections caused by Gram-negative bacteria, including drug-resistant strains.

公开(公告)号：US20180086762A1

公开(公告)日：2018-03-29

申请号：US15718571

申请日：2017-09-28

Applicant: Novartis AG

Inventor： Anthony CASAREZ ,  Markus FUREGATI ,  Guido KOCH ,  Xiaodong LIN ,  Flavio OSSOLA ,  Folkert RECK ,  Robert Lowell SIMMONS ,  Qingming ZHU

IPC: C07D471/18 ,  A61K31/439 ,  A61K31/431 ,  A61K31/427 ,  A61K31/546 ,  A61K31/407 ,  A61K31/496

CPC classification number: C07D471/18 ,  A61K31/407 ,  A61K31/427 ,  A61K31/431 ,  A61K31/439 ,  A61K31/496 ,  A61K31/5025 ,  A61K31/535 ,  A61K31/546 ,  A61K31/551 ,  A61K45/06 ,  A61P31/04 ,  C07B2200/13 ,  A61K2300/00

Abstract: This invention pertains generally to compounds of Formula (A), as further described herein, which act as beta-lactamase inhibitors, and salts, crystalline forms and formulations thereof. In certain aspects, the invention pertains to methods of using such compounds in combination with a beta-lactam antibiotic to treat infections caused by Gram-negative bacteria, including drug-resistant strains.