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公开(公告)号:US20240245694A1
公开(公告)日:2024-07-25
申请号:US18483651
申请日:2023-10-10
Applicant: Novartis AG
Inventor: Vincent BORDAS , Markus FUREGATI , Jacques HAMON , Jürgen Hans-Hermann HINRICHS , Ziyue HONG , Fabio LIMA , Fatma LIMAM , Henrik MOEBITZ , Sandro NOCITO , Niko SCHMIEDEBERG , Joseph SCHOEPFER , Ross Sinclair STRANG , Frédéric ZECRI , Huangchao YU , Yong ZHANG , Xinkan YANG , Sisi ZHANG , Wei LI
IPC: A61K31/5377 , A61K31/519 , C07D487/14 , C07D519/00
CPC classification number: A61K31/5377 , A61K31/519 , C07D487/14 , C07D519/00
Abstract: The present invention provides a compound, or a pharmaceutically acceptable salt thereof, of formula (I):
wherein R1, R2, R3, x, R4, R5, y, R, M, W, L, V, T, Y, J, K and A are as described herein, therapeutic uses of said compounds, uses of said compounds as research chemicals, a pharmaceutical composition and combinations comprising said compounds, and methods for manufacturing the compounds of the invention.-
公开(公告)号:US20240360118A1
公开(公告)日:2024-10-31
申请号:US18506164
申请日:2023-11-10
Applicant: Novartis AG
Inventor: Vincent BORDAS , Jvan BRUN , Andrea DECKER , Markus FUREGATI , Geoffrey GOGNIAT , Wanben GONG , Jacques HAMON , Jürgen Hans-Hermann HINRICHS , Philipp HOLZER , Fatma LIMAM , Henrik MÖBITZ , Sandro NOCITO , Simone PLATTNER , Niko SCHMIEDEBERG , Joseph SCHOEPFER , Jessica SOTO , Ross Sinclair STRANG , Shuping YAO , Huangchao YU , Frédéric ZECRI , Sisi ZHANG
IPC: C07D413/14 , C07D401/14 , C07D405/14
CPC classification number: C07D413/14 , C07D401/14 , C07D405/14 , C07B2200/13
Abstract: The present invention provides a compound, or a pharmaceutically acceptable salt thereof, of formula (I):
wherein R1, R2, R3, R4, R5, R26, R27, y, R, M, W, L, V, T, Y, J, K and A are as described herein, therapeutic uses of said compounds, uses of said compounds as research chemicals, a pharmaceutical composition and combinations comprising said compounds, and methods for manufacturing the compounds of the invention.-
公开(公告)号:US20230046859A1
公开(公告)日:2023-02-16
申请号:US17824407
申请日:2022-05-25
Applicant: NOVARTIS AG
Inventor: Vincent BORDAS , Jvan BRUN , Andrea DECKER , Markus FUREGATI , Geoffrey GOGNIAT , Wanben GONG , Jacques HAMON , Jürgen Hans-Hermann HINRICHS , Philipp HOLZER , Fatma LIMAM , Henrik MÖBITZ , Sandro NOCITO , Simone PLATTNER , Niko SCHMIEDEBERG , Joseph SCHOEPFER , Jessica SOTO , Ross Sinclair STRANG , Shuping YAO , Huangchao YU , Frédéric ZECRI , Sisi ZHANG
IPC: C07D413/14 , C07D401/14 , C07D405/14
Abstract: The present invention provides a compound, or a pharmaceutically acceptable salt thereof, of formula (I): wherein R1, R2, R3, R4, R5, R26, R27, y, R, M, W, L, V, T, Y, J, K and A are as described herein, therapeutic uses of said compounds, uses of said compounds as research chemicals, a pharmaceutical composition and combinations comprising said compounds, and methods for manufacturing the compounds of the invention.
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公开(公告)号:US20190177324A1
公开(公告)日:2019-06-13
申请号:US16323668
申请日:2017-09-28
Applicant: Novartis AG
Inventor: Anthony CASAREZ , Markus FUREGATI , Guido KOCH , Xiaodong LIN , Flavio OSSOLA , Folkert RECK , Robert Lowell SIMMONS , Qingming ZHU
IPC: C07D471/18 , A61P31/04 , A61K31/439 , A61K31/4545 , A61K31/427 , A61K31/546 , A61K31/407 , A61K31/496
Abstract: This invention pertains generally to compounds of Formula (A), as further described herein, which act as beta-lactamase inhibitors, and salts, crystalline forms and formulations thereof. In certain aspects, the invention pertains to methods of using such compounds in combination with a beta-lactam antibiotic to treat infections caused by Gram-negative bacteria, including drug-resistant strains.
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公开(公告)号:US20180086762A1
公开(公告)日:2018-03-29
申请号:US15718571
申请日:2017-09-28
Applicant: Novartis AG
Inventor: Anthony CASAREZ , Markus FUREGATI , Guido KOCH , Xiaodong LIN , Flavio OSSOLA , Folkert RECK , Robert Lowell SIMMONS , Qingming ZHU
IPC: C07D471/18 , A61K31/439 , A61K31/431 , A61K31/427 , A61K31/546 , A61K31/407 , A61K31/496
CPC classification number: C07D471/18 , A61K31/407 , A61K31/427 , A61K31/431 , A61K31/439 , A61K31/496 , A61K31/5025 , A61K31/535 , A61K31/546 , A61K31/551 , A61K45/06 , A61P31/04 , C07B2200/13 , A61K2300/00
Abstract: This invention pertains generally to compounds of Formula (A), as further described herein, which act as beta-lactamase inhibitors, and salts, crystalline forms and formulations thereof. In certain aspects, the invention pertains to methods of using such compounds in combination with a beta-lactam antibiotic to treat infections caused by Gram-negative bacteria, including drug-resistant strains.
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