公开(公告)号：US20250115572A1

公开(公告)日：2025-04-10

申请号：US18729949

申请日：2023-01-20

Applicant: Novartis AG

Inventor： Christopher M. ADAMS ,  Lara C. CZABANIUK ,  Stefanie FLOHR ,  François GESSIER ,  Michael Christoph HEDIGER ,  Konstanze HURTH ,  Nancy LABBE-GIGUERE ,  Fabio LIMA ,  Tajesh PATEL ,  Oliver SIMIC ,  Martin SENDZIK ,  Angela VITREY ,  Anna VULPETTI

IPC: C07D401/06 ,  A61K31/438 ,  A61K31/444 ,  C07D401/14 ,  C07D405/14

Abstract: Provided herein are compounds of formula (I) and pharmaceutical compositions thereof useful for treating diseases or disorders mediated by the complement factor B. (I).

公开(公告)号：US20230312483A1

公开(公告)日：2023-10-05

申请号：US18309948

申请日：2023-05-01

Applicant: Novartis AG

Inventor： Daniela ANGST ,  François GESSIER ,  Anna VULPETTI

IPC: C07D239/47 ,  C07D403/12 ,  C07D401/14 ,  C07D401/10 ,  C07D401/12 ,  C07D405/12 ,  A61P29/00 ,  A61P35/02 ,  A61K31/505 ,  A61K31/506

CPC classification number: C07D239/47 ,  C07D403/12 ,  C07D401/14 ,  C07D401/10 ,  C07D401/12 ,  C07D405/12 ,  A61P29/00 ,  A61P35/02 ,  A61K31/505 ,  A61K31/506

Abstract: The present invention describes new amino pyrimidine derivatives and pharmaceutically acceptable salts thereof which appear to interact with Bruton's tyrosine kinase (Btk). Accordingly, the novel amino pyrimidines may be effective in the treatment of autoimmune disorders, inflammatory diseases, allergic diseases, airway diseases, such as asthma and chronic obstructive pulmonary disease (COPD), transplant rejection, cancers e.g. of hematopoietic origin or solid tumors.