公开(公告)号：US20240336598A1

公开(公告)日：2024-10-10

申请号：US18589841

申请日：2024-02-28

Applicant: Novartis AG

Inventor： Daniela ANGST ,  Philippe Bolduc ,  Matthew William Carson ,  Atwood Kim CHEUNG ,  Véronique Darsigny ,  Xiang GAO ,  Viktor HORNAK ,  Keith JENDZA ,  Rajesh KARKI ,  Ajay Kumar LAL ,  Gang LIU ,  Justin Yik Ching MAO ,  Jeffrey M. McKENNA ,  Erik MEREDITH ,  Muneto MOGI ,  Vivek RAUNIYAR ,  Liansheng SU ,  Ritesh TICHKULE ,  Shuangxi WANG ,  Chun ZHANG ,  Liang ZHAO ,  Rui ZHENG

IPC: C07D403/14 ,  A61K31/517 ,  A61K31/55 ,  A61K45/06 ,  C07D239/95 ,  C07D401/12 ,  C07D401/14

CPC classification number: C07D403/14 ,  A61K31/517 ,  A61K31/55 ,  A61K45/06 ,  C07D239/95 ,  C07D401/12 ,  C07D401/14

Abstract: The disclosure relates to a compound of Formula (I):




or a pharmaceutically acceptable salt thereof wherein A, Ra to Rd, and R4 to R7, are as described herein, as well as compositions and methods of using such compounds.

公开(公告)号：US20230312483A1

公开(公告)日：2023-10-05

申请号：US18309948

申请日：2023-05-01

Applicant: Novartis AG

Inventor： Daniela ANGST ,  François GESSIER ,  Anna VULPETTI

IPC: C07D239/47 ,  C07D403/12 ,  C07D401/14 ,  C07D401/10 ,  C07D401/12 ,  C07D405/12 ,  A61P29/00 ,  A61P35/02 ,  A61K31/505 ,  A61K31/506

CPC classification number: C07D239/47 ,  C07D403/12 ,  C07D401/14 ,  C07D401/10 ,  C07D401/12 ,  C07D405/12 ,  A61P29/00 ,  A61P35/02 ,  A61K31/505 ,  A61K31/506

Abstract: The present invention describes new amino pyrimidine derivatives and pharmaceutically acceptable salts thereof which appear to interact with Bruton's tyrosine kinase (Btk). Accordingly, the novel amino pyrimidines may be effective in the treatment of autoimmune disorders, inflammatory diseases, allergic diseases, airway diseases, such as asthma and chronic obstructive pulmonary disease (COPD), transplant rejection, cancers e.g. of hematopoietic origin or solid tumors.

公开(公告)号：US20180251432A1

公开(公告)日：2018-09-06

申请号：US15974190

申请日：2018-05-08

Applicant: Novartis AG

Inventor： Daniela ANGST ,  Francois GESSIER ,  Anna VULPETTI

IPC: C07D239/47 ,  A61K31/505 ,  A61P35/02 ,  A61P29/00 ,  A61K31/506 ,  C07D401/12 ,  C07D401/10 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12

Abstract: The present invention describes new amino pyrimidine derivatives and pharmaceutically acceptable salts thereof which appear to interact with Bruton's tyrosine kinase (Btk). Accordingly, the novel amino pyrimidines may be effective in the treatment of autoimmune disorders, inflammatory diseases, allergic diseases, airway diseases, such as asthma and chronic obstructive pulmonary disease (COPD), transplant rejection, cancers e.g. of hematopoietic origin or solid tumors.