公开(公告)号：US20240052354A1

公开(公告)日：2024-02-15

申请号：US18048015

申请日：2022-10-19

Applicant: NOVARTIS AG

Inventor： Eric BILLY ,  Antoine DE WECK ,  Javad GOLJI ,  Gregory HOFFMAN ,  Francesco HOFMANN ,  Audrey KAUFFMANN ,  Konstantinos John MAVRAKIS ,  Earl Robert MCDONALD, III ,  William SELLERS ,  Tobias SCHMELZLE ,  Frank Peter STEGMEIER ,  Michael Ray SCHLABACH, JR.

IPC: C12N15/115 ,  A61K45/06 ,  C12N9/22 ,  C12N15/113 ,  G01N33/574 ,  A61K47/18

CPC classification number: C12N15/115 ,  A61K45/06 ,  C12N9/22 ,  C12N15/113 ,  G01N33/574 ,  A61K47/18 ,  C12N2310/20 ,  C12N2310/14 ,  G01N2800/52

Abstract: The disclosure provides novel personalized therapies, kits, transmittable forms of information and methods for use in treating patients having cancer, wherein the cancer is amenable to therapeutic treatment with an inhibitor, e.g., an inhibitor of any of the targets disclosed herein. Kits, methods of screening for candidate inhibitors, and associated methods of treatment are also provided.

公开(公告)号：US20250101435A1

公开(公告)日：2025-03-27

申请号：US18664977

申请日：2024-05-15

Applicant: Novartis AG

Inventor： Eric BILLY ,  Antoine DE WECK ,  Javad GOLJI ,  Gregory HOFFMAN ,  Francesco HOFMANN ,  Audrey KAUFFMANN ,  Konstantinos John MAVRAKIS ,  Earl Robert MCDONALD, III ,  William SELLERS ,  Tobias SCHMELZLE ,  Frank Peter STEGMEIER ,  Michael Ray SCHLABACH, Jr.

IPC: C12N15/115 ,  A61K45/06 ,  A61K47/18 ,  C12N9/22 ,  C12N15/113 ,  G01N33/574

Abstract: The disclosure provides novel personalized therapies, kits, transmittable forms of information and methods for use in treating patients having cancer, wherein the cancer is amenable to therapeutic treatment with an inhibitor, e.g., an inhibitor of any of the targets disclosed herein. Kits, methods of screening for candidate inhibitors, and associated methods of treatment are also provided.

公开(公告)号：US20210155932A1

公开(公告)日：2021-05-27

申请号：US16632777

申请日：2018-07-20

Applicant: NOVARTIS AG

Inventor： Eric BILLY ,  Antoine DEWECK ,  Javad GOLJI ,  Gregory HOFFMAN ,  Francesco HOFMANN ,  Audrey KAUFFMANN ,  Konstantinos John MAVRAKIS ,  Earl Robert MCDONALD, III ,  William SELLERS ,  Tobias SCHMELZLE ,  Frank Peter STEGMEIER ,  Michael Ray SCHLABACH, Jr.

IPC: C12N15/115 ,  C12N15/113 ,  C12N9/22 ,  A61K45/06 ,  G01N33/574

Abstract: The disclosure provides novel personalized therapies, kits, transmittable forms of information and methods for use in treating patients having cancer, wherein the cancer is amenable to therapeutic treatment with an inhibitor, e.g., an inhibitor of any of the targets disclosed herein. Kits, methods of screening for candidate inhibitors, and associated methods of treatment are also provided.