公开(公告)号：US20240238305A1

公开(公告)日：2024-07-18

申请号：US18561444

申请日：2022-05-18

Applicant: Novartis AG

Inventor： Yi FAN ,  Declan HARDY ,  Zhihong HUANG ,  Jay Parthiban LAKSHMAN ,  Jon Christopher LOREN ,  Valentina MOLTENI ,  Sunil Kumar Mandala RAYABANDLA ,  Nuria Jimenez RIDRUEJO ,  Duncan SHAW ,  Jeffrey SMITH ,  Christopher Stephen TOWLER

IPC: A61K31/5377 ,  A61K9/00 ,  A61K9/10 ,  A61K47/10 ,  A61K47/18 ,  A61K47/26 ,  A61K47/32 ,  A61K47/44 ,  A61P27/04

CPC classification number: A61K31/5377 ,  A61K9/0048 ,  A61K9/10 ,  A61K47/10 ,  A61K47/18 ,  A61K47/26 ,  A61K47/32 ,  A61K47/44 ,  A61P27/04

Abstract: Formulations of 3-((3-(4-(2-(isobutylsulfonyl)phenoxy)-3-(trifluoromethyl)phenyl)-1,2,4-oxadiazol-5-yl)methyl)-5,5-dimethyl-1-(2-morpholinoethyl)imidazolidine-2,4-dione and pharmaceutically acceptable salts thereof, processes for their production, and uses thereof, including in the treatment of ocular diseases and disorders such as dry eye disease and Meibomian gland dysfunction (MGD).

公开(公告)号：US20220162170A1

公开(公告)日：2022-05-26

申请号：US17430819

申请日：2020-02-13

Applicant: Novartis AG

Inventor： Joseph Paul BULLOCK ,  Chinmay MAHESHWARI ,  Quintus MEDLEY ,  Muneto MOGI ,  Michela MONTECCHI-PALMER ,  Gregory MORANDI ,  Michael MUTZ ,  Kalliopi STASI ,  Christopher Stephen TOWLER

IPC: C07D239/91

Abstract: The present disclosure provides polymorphs and formulations of 4-(7-hydroxy-2-isopropyl-4-oxo-4H-quinazolin-3-yl)-benzonitrile (compound I). The present disclosure further provides methods for treating ocular surface pain by administering 4-(7-hydroxy-2-isopropyl-4-oxo-4H-quinazolin-3-yl)-benzonitrile (compound I). The present invention also provides methods for treating dry eye disease and ocular hyperemia by administering 4-(7-hydroxy-2-isopropyl-4-oxo-4H-quinazolin-3-yl)-benzonitrile.