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公开(公告)号：US20140343084A1
公开(公告)日：2014-11-20
申请号：US14327639
申请日：2014-07-10
Applicant: Novartis AG
Inventor： Pascal FURET , Vito GUAGNANO , Philipp HOLZER , Joerg KALLEN , Lv LIAO , Robert MAH , Liang MAO , Keiichi MASUYA , Achim SCHLAPBACH , Stefan STUTZ , Andrea VAUPEL
IPC: C07D487/04
CPC classification number: C07D487/04 , A61K31/4188 , A61K31/4439 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K31/541 , A61K45/06
Abstract: The invention relates to compounds of formula (I): as described herein, pharmaceutical preparations comprising such compounds, uses and methods of use for such compounds in the treatment of a disorder or a disease mediated by the activity of MDM2 and/or MDM4, and combinations comprising such compounds.
Abstract translation: 本发明涉及式（I）化合物：如本文所述，包含这些化合物的药物制剂，用于治疗由MDM2和/或MDM4的活性介导的疾病或疾病的这些化合物的用途和方法，以及 包含这些化合物的组合。
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公开(公告)号：US20190231760A1
公开(公告)日：2019-08-01
申请号：US16289612
申请日：2019-02-28
Applicant: NOVARTIS AG
Inventor： Nicole BUSCHMANN , Robin Alec FAIRHURST , Pascal FURET , Diana GRAUS PORTA , Carolina HAEFLIGER , Bo HAN , Thomas KNOPFEL , Catherine LEBLANC , Lv LIAO , Robert MAH , Masato MURAKAMI , Pierre NIMSGERN , Michael PALMER , Dale PORTER , Sebastien RIPOCHE , Can WANG , Youzhen WANG , Andreas WEISS , Jing XIONG , Xianglin ZHAO
IPC: A61K31/4375 , A61P35/00 , A61K31/4545 , A61K31/496 , A61K31/55
Abstract: The present invention relates to therapeutic uses of compounds of formula (I) or a pharmaceutically acceptable salt thereof
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公开(公告)号：US20180111932A1
公开(公告)日：2018-04-26
申请号：US15788248
申请日：2017-10-19
Applicant: NOVARTIS AG
Inventor： Guillaume BARBE , Gregory Raymond BEBERNITZ , Sicong GENG , Hatice Belgin GULGEZE EFTHYMIOU , Lv LIAO , Fupeng MA , Ruowei MO , David Thomas PARKER , Yunshan PENG , Stefan PEUKERT , Ken YAMADA , Kayo YASOSHIMA
IPC: C07D471/04 , A61K31/4375 , A61K45/06 , A61K31/496 , A61K31/5377 , A61K31/541 , C07F9/6561 , A61K31/675
CPC classification number: C07D471/04 , A61K31/4375 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K31/675 , A61K45/06 , A61P9/06 , C07B2200/13 , C07F9/6561
Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; Wherein R1, R3-R6, X2 and X3 are as defined herein, a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
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公开(公告)号：US20210284635A1
公开(公告)日：2021-09-16
申请号：US17071311
申请日：2020-10-15
Applicant: NOVARTIS AG
Inventor： Guillaume BARBE , Gregory Raymond BEBERNITZ , Sicong GENG , Hatice Belgin GULGEZE EFTHYMIOU , Lv LIAO , Fupeng MA , Ruowei MO , David Thomas PARKER , Yunshan PENG , Stefan PEUKERT , Nichola Smith , Ken YAMADA , Kayo YASOSHIMA
IPC: C07D471/04 , A61P9/06 , A61K31/4375 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K31/675 , A61K45/06 , C07F9/6561
Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; Wherein R1, R3-R6, X2 and X3 are as defined herein, a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
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公开(公告)号：US20190263803A1
公开(公告)日：2019-08-29
申请号：US16290313
申请日：2019-03-01
Applicant: NOVARTIS AG
Inventor： Guillaume BARBE , Gregory Raymond BEBERNITZ , Sicong GENG , Hatice Belgin GULGEZE EFTHYMIOU , Lv LIAO , Fupeng MA , Ruowei MO , David Thomas PARKER , Yunshan PENG , Stefan PEUKERT , Ken YAMADA , Kayo YASOSHIMA
IPC: C07D471/04 , A61P9/06 , A61K31/675 , A61K31/496 , A61K31/5377 , A61K31/4375 , C07F9/6561 , A61K45/06 , A61K31/541
Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; Wherein R1, R3-R6, X2 and X3 are as defined herein, a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
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Patent Agency Ranking
公开(公告)号：US20210155606A1
公开(公告)日：2021-05-27
申请号：US17170690
申请日：2021-02-08
Applicant: NOVARTIS AG
Inventor： Luca ARISTA , Sreehari BABU , Jianwei BIAN , Kai CUI , Michael Patrick DILLON , Rene LATTMANN , Jialiang LI , Lv LIAO , Dimitrios LIZOS , Rita RAMOS , Nikolaus Johannes STIEFL , Thomas ULLRICH , Peggy USSELMANN , Xiaoyang WANG , Liladhar Murlidhar WAYKOLE , Sven WEILER , Yubo ZHANG , Yizong ZHOU , Tingying ZHU
IPC: C07D401/14 , C07D405/14 , C07D401/10 , C07D401/12 , C07D409/14 , C07D213/82 , C07D411/14 , C07D491/107 , A61P19/00 , C07D417/00 , C07D413/00 , C07D419/00 , A61P19/08 , C07D413/10 , C07D413/12 , C07D413/14 , C07D491/20
Abstract: The invention relates to a compound of formula (1) in free form or in pharmaceutically acceptable salt form to pharmaceutical compositions comprising said compound and to the use of said compound in the treatment of heterotopic ossification and fibrodysplasia ossificans progressiva.
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公开(公告)号：US20180185341A1
公开(公告)日：2018-07-05
申请号：US15516443
申请日：2015-10-02
Applicant: Novartis AG
Inventor： Nicole BUSCHMANN , Robin Alec FAIRHURST , Pascal FURET , Diana GRAUS PORTA , Carolina HAEFLIGER , Bo HAN , Thomas KNÖPFEL , Catherine LEBLANC , Lv LIAO , Robert MAH , Masato MURAKAMI , Pierre NIMSGERN , Michael PALMER , Dale PORTER , Sebastien RIPOCHE , Can WANG , Youzhen WANG , Andreas WEISS , Jing XIONG , Xianglin ZHAO
IPC: A61K31/4375 , A61K31/496 , A61P35/00
CPC classification number: A61K31/4375 , A61K31/4545 , A61K31/496 , A61K31/55 , A61P35/00
Abstract: The present invention relates to therapeutic uses of compounds of formula (I) or a pharmaceutically acceptable salt thereof
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公开(公告)号：US20200299265A1
公开(公告)日：2020-09-24
申请号：US16884666
申请日：2020-05-27
Applicant: NOVARTIS AG
Inventor： Luca ARISTA , Sreehari BABU , Jianwei BIAN , Kai CUI , Michael Patrick DILLON , Rene LATTMANN , Jialiang LI , Lv LIAO , Dimitrios LIZOS , Rita RAMOS , Nikolaus Johannes STIEFL , Thomas ULLRICH , Peggy USSELMANN , Xiaoyang WANG , Liladhar Murlidhar WAYKOLE , Sven WEILER , Yubo ZHANG , Yizong ZHOU , Tingying ZHU
IPC: C07D401/14 , C07D405/14 , C07D401/10 , C07D401/12 , C07D409/14 , C07D213/82 , C07D411/14 , C07D491/107 , A61P19/00 , C07D417/00 , C07D413/00 , C07D419/00 , A61P19/08 , C07D413/10 , C07D413/12 , C07D413/14 , C07D491/20
Abstract: The invention relates to a compound of formula (I) in free form or in pharmaceutically acceptable salt form to pharmaceutical compositions comprising said compound and to the use of said compound in the treatment of heterotopic ossification and fibrodysplasia ossificans progressiva.
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公开(公告)号：US20190161474A1
公开(公告)日：2019-05-30
申请号：US16318250
申请日：2017-07-18
Applicant: NOVARTIS AG
Inventor： Luca ARISTA , Sreehari BABU , Jianwei BIAN , Kai CUI , Michael Patrick DILLON , Rene LATTMANN , Jialiang LI , Lv LIAO , Dimitrios LIZOS , Rita RAMOS , Nikolaus Johannes STIEFL , Thomas ULLRICH , Peggy USSELMANN , Xiaoyang WANG , Liladhar Murlidhar WAYKOLE , Sven WEILER , Yubo ZHANG , Yizong ZHOU , Tingying ZHU
IPC: C07D401/14 , C07D401/10 , C07D401/12 , C07D491/20 , C07D405/14 , C07D409/14 , C07D413/10 , C07D413/12 , C07D413/14 , A61P19/08
Abstract: The invention relates to a compound of formula (I) in free form or in pharmaceutically acceptable salt form (I) to pharmaceutical compositions comprising said compound and to the use of said compound in the treatment of heterotopic ossification and fibrodysplasia ossificans progressiva.
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公开(公告)号：US20190076412A1
公开(公告)日：2019-03-14
申请号：US16190087
申请日：2018-11-13
Applicant: NOVARTIS AG
Inventor： Nicole BUSCHMANN , Robin Alec FAIRHURST , Pascal FURET , Thomas KNÖPFEL , Catherine LEBLANC , Lv LIAO , Robert MAH , Pierre NIMSGERN , Sebastien RIPOCHE , Jing XIONG , Bo HAN , Can WANG , Xianglin ZHAO
IPC: A61K31/4375 , A61K31/4545 , A61P35/00 , A61K31/55 , A61K31/496
Abstract: The present invention relates to therapeutic uses of compounds of formula (1) or a pharmaceutically acceptable salt thereof.
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