公开(公告)号：US20190105197A1

公开(公告)日：2019-04-11

申请号：US16130330

申请日：2018-09-13

Applicant: Novartis AG

Inventor： Mark David LaBelle ,  Brian William McDonell

IPC: A61F9/00 ,  A61M5/32

Abstract: Devices and methods are provided for injection of a therapeutic agent into an area beneath eye tissue, such as a sub-retinal area or a suprachoroidal area. Example devices comprise an injector housing, a tubular element (needle or microcatheter), a first area within the injector housing configured to be selectively in fluid communication with the tubular element for delivery of a bleb-formation fluid, and a second area within the injector housing configured to be selectively in fluid communication with the tubular element for delivery of a therapeutic agent into the area beneath eye tissue. In some embodiments, the first area is a chamber within the injector housing, and the second area is an internal area of a tube within the chamber. The devices and methods allow, with a single needle (or microcatheter) insertion, high pressure bleb formation and low pressure delivery of fragile therapeutic agent compositions.

公开(公告)号：US10939815B2

公开(公告)日：2021-03-09

申请号：US15793656

申请日：2017-10-25

Applicant: Novartis AG

Inventor： Mark David LaBelle ,  Ryan Takakawa ,  Alireza Mirsepassi ,  Cesario Dos Santos ,  Gerald David Bacher ,  Eyad Ammari

IPC: A61F9/008 ,  A61B3/00 ,  A61B90/30 ,  A61F9/007 ,  F21V8/00

Abstract: The present disclosure provides a vitreous visualization system including a general light source, a general conduit that transmits light from the general light source through a conduit portion of a general illumination optical fiber, and a combined vitreous visualization and general illumination tool that receives light from the general conduit. The combined vitreous visualization tool includes a vitreous visualization light source, a controller for the vitreous visualization light source, a vitreous visualization optical fiber, a tool portion of the general illumination optical fiber, and a probe tip through which at least parts of both the vitreous visualization optical fiber and the tool portion of the general illumination optical fiber pass.

公开(公告)号：US20180140179A1

公开(公告)日：2018-05-24

申请号：US15793656

申请日：2017-10-25

Applicant: Novartis AG

Inventor： Mark David LaBelle ,  Ryan Takakawa ,  Alireza Mirsepassi ,  Cesario Dos Santos ,  Gerald David Bacher ,  Eyad Ammari

IPC: A61B3/00 ,  A61F9/007 ,  F21V8/00

CPC classification number: A61B3/0008 ,  A61B90/30 ,  A61B2090/306 ,  A61F9/007 ,  G02B6/0008

Abstract: The present disclosure provides a vitreous visualization system including a general light source, a general conduit that transmits light from the general light source through a conduit portion of a general illumination optical fiber, and a combined vitreous visualization and general illumination tool that receives light from the general conduit. The combined vitreous visualization tool includes a vitreous visualization light source, a controller for the vitreous visualization light source, a vitreous visualization optical fiber, a tool portion of the general illumination optical fiber, and a probe tip through which at least parts of both the vitreous visualization optical fiber and the tool portion of the general illumination optical fiber pass.