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公开(公告)号:US10934285B2
公开(公告)日:2021-03-02
申请号:US16309076
申请日:2017-06-12
申请人: Novartis AG
发明人: Zhuoliang Chen , Jorge Garcia Fortanet , Rajesh Karki , Matthew J. Lamarche , Dyuti Majumdar , Lawrence Blas Perez , Martin Sendzik , Troy Douglas Smith , Fan Yang , Bing Yu
IPC分类号: C07D487/14 , C07D471/04 , C07D401/14 , C07D403/14 , C07D455/02 , C07D487/04 , C07D495/04 , C07D513/04 , C07D519/00
摘要: The present invention relates to compounds of formula I: in which Y1, Y2, R1, R2 and R3 are defined in the Summary of the Invention; capable of inhibiting the activity of SHP2. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds and compositions in the management of diseases or disorders associated with the aberrant activity of SHP2.