公开(公告)号：US20220112189A1

公开(公告)日：2022-04-14

申请号：US17499663

申请日：2021-10-12

Applicant: Novartis AG

Inventor： Joseph Michael Young ,  Michael Robert Turner ,  Peichao Lu

IPC: C07D471/04 ,  A61K45/06 ,  A61P33/02

Abstract: The invention relates to compounds of Formula I: or a pharmaceutically acceptable salt, tautomer, or stereoisomer, thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds and methods of using such compounds for method for treating, preventing, inhibiting, ameliorating, or eradicating the pathology and/or symptomology of cryptosporidiosis by administering such a compound.

公开(公告)号：US12018024B2

公开(公告)日：2024-06-25

申请号：US17499663

申请日：2021-10-12

Applicant: Novartis AG

Inventor： Joseph Michael Young ,  Michael Robert Turner ,  Peichao Lu

IPC: C07D471/04 ,  A61K45/06 ,  A61P33/02

CPC classification number: C07D471/04 ,  A61K45/06 ,  A61P33/02

Abstract: The invention relates to compounds of Formula I:






or a pharmaceutically acceptable salt, tautomer, or stereoisomer, thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds and methods of using such compounds for method for treating, preventing, inhibiting, ameliorating, or eradicating the pathology and/or symptomology of cryptosporidiosis by administering such a compound.

公开(公告)号：US20230365511A1

公开(公告)日：2023-11-16

申请号：US18164974

申请日：2023-02-06

Applicant: Novartis AG ,  Gilead Sciences, Inc.

Inventor： Zef Konst ,  Yipin Lu ,  Robert Joseph Moreau ,  Naomi Samadara Rajapaksa ,  Galen Shearn-Nance ,  David Charles Tully ,  Michael Robert Turner ,  Joseph Michael Young ,  Qian Zhao ,  Britton K. Corkey ,  Samuel E. Metobo

IPC: C07D243/10

CPC classification number: C07D243/10

Abstract: The invention provides compounds of Formula (I)





as described herein, along with pharmaceutically acceptable salts, pharmaceutical compositions containing such compounds, and methods to use these compounds, salts and compositions for treating viral infections, particularly infections caused by herpesviruses.

公开(公告)号：US11667613B2

公开(公告)日：2023-06-06

申请号：US17030540

申请日：2020-09-24

Applicant: Novartis AG ,  Gilead Sciences, Inc.

Inventor： Zef Konst ,  Yipin Lu ,  Robert Joseph Moreau ,  Naomi Samadara Rajapaksa ,  Galen Shearn-Nance ,  David Charles Tully ,  Michael Robert Turner ,  Joseph Michael Young ,  Qian Zhao ,  Britton K. Corkey ,  Samuel E. Metobo

IPC: C07D471/04 ,  C07D471/14 ,  A61K31/4162 ,  A61K31/437 ,  A61P31/22 ,  C07D243/10

CPC classification number: C07D243/10

Abstract: The invention provides compounds of Formula (I)




as described herein, along with pharmaceutically acceptable salts, pharmaceutical compositions containing such compounds, and methods to use these compounds, salts and compositions for treating viral infections, particularly infections caused by herpesviruses.