公开(公告)号：US10301312B2

公开(公告)日：2019-05-28

申请号：US15965172

申请日：2018-04-27

Applicant: Novartis AG

Inventor： Jiping Fu ,  Wooseok Han ,  Subramanian Karur ,  Peichao Lu ,  Keith Bruce Pfister ,  Joseph Michael Young

IPC: C07D471/14 ,  C07D405/12 ,  A61P31/12 ,  C07D491/16 ,  C07D401/12 ,  A61K45/06 ,  A61K31/4985 ,  C07D471/22

Abstract: The invention provides compounds of Formula (I) as described herein, along with pharmaceutically acceptable salts, pharmaceutical compositions containing such compounds, and methods to use these compounds, salts and compositions for treating viral infections, particularly infections caused by hepatitis B virus, and reducing the occurrence of serious conditions associated with HBV.

公开(公告)号：US20220112189A1

公开(公告)日：2022-04-14

申请号：US17499663

申请日：2021-10-12

Applicant: Novartis AG

Inventor： Joseph Michael Young ,  Michael Robert Turner ,  Peichao Lu

IPC: C07D471/04 ,  A61K45/06 ,  A61P33/02

Abstract: The invention relates to compounds of Formula I: or a pharmaceutically acceptable salt, tautomer, or stereoisomer, thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds and methods of using such compounds for method for treating, preventing, inhibiting, ameliorating, or eradicating the pathology and/or symptomology of cryptosporidiosis by administering such a compound.

公开(公告)号：US10975078B2

公开(公告)日：2021-04-13

申请号：US16808985

申请日：2020-03-04

Applicant: Novartis AG

Inventor： Jiping Fu ,  Wooseok Han ,  Subramanian Karur ,  Peichao Lu ,  Keith Bruce Pfister ,  Joseph Michael Young

IPC: C07D471/14 ,  C07D405/12 ,  A61P31/12 ,  C07D491/16 ,  C07D401/12 ,  A61K45/06 ,  A61K31/4985 ,  C07D471/22

Abstract: The invention provides compounds of Formula (I) as described herein, along with pharmaceutically acceptable salts, pharmaceutical compositions containing such compounds, and methods to use these compounds, salts and compositions for treating viral infections, particularly infections caused by hepatitis B virus, and reducing the occurrence of serious conditions associated with HBV.

公开(公告)号：US20220105091A1

公开(公告)日：2022-04-07

申请号：US17551080

申请日：2021-12-14

Applicant: Novartis AG

Inventor： Jiping Fu ,  Wooseok Han ,  Xianming Jin ,  Keith Bruce Pfister ,  Joseph Michael Young

IPC: A61K31/4985 ,  A61K47/60 ,  A61P31/20 ,  A01N43/90 ,  A61K38/21 ,  A61K45/06 ,  C07D471/14

Abstract: The invention provides compounds of Formula (I) as described herein, along with pharmaceutically acceptable salts, pharmaceutical compositions and pharmaceutical combinations containing such compounds, as well as methods to use these compounds, salts and compositions for treating viral infections, particularly infections caused by hepatitis B virus (HBV), and for reducing the occurrence of serious conditions associated with HBV.

公开(公告)号：US09845325B2

公开(公告)日：2017-12-19

申请号：US15435137

申请日：2017-02-16

Applicant: Novartis AG

Inventor： Jiping Fu ,  Xianming Jin ,  Patrick Lee ,  Peichao Lu ,  Joseph Michael Young

IPC: C07D491/147 ,  C07D471/14 ,  A61K31/4375

CPC classification number: C07D471/14 ,  A61K31/4375 ,  C07D217/08 ,  C07D491/14 ,  C07D491/147

Abstract: The invention provides compounds of Formula (I) as described herein, along with pharmaceutically acceptable salts, pharmaceutical compositions containing such compounds, and methods to use these compounds, salts and compositions for treating viral infections, particularly infections caused by hepatitis B virus, and reducing the occurrence of serious conditions associated with HBV.

公开(公告)号：US12018024B2

公开(公告)日：2024-06-25

申请号：US17499663

申请日：2021-10-12

Applicant: Novartis AG

Inventor： Joseph Michael Young ,  Michael Robert Turner ,  Peichao Lu

IPC: C07D471/04 ,  A61K45/06 ,  A61P33/02

CPC classification number: C07D471/04 ,  A61K45/06 ,  A61P33/02

Abstract: The invention relates to compounds of Formula I:






or a pharmaceutically acceptable salt, tautomer, or stereoisomer, thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds and methods of using such compounds for method for treating, preventing, inhibiting, ameliorating, or eradicating the pathology and/or symptomology of cryptosporidiosis by administering such a compound.

公开(公告)号：US20230365511A1

公开(公告)日：2023-11-16

申请号：US18164974

申请日：2023-02-06

Applicant: Novartis AG ,  Gilead Sciences, Inc.

Inventor： Zef Konst ,  Yipin Lu ,  Robert Joseph Moreau ,  Naomi Samadara Rajapaksa ,  Galen Shearn-Nance ,  David Charles Tully ,  Michael Robert Turner ,  Joseph Michael Young ,  Qian Zhao ,  Britton K. Corkey ,  Samuel E. Metobo

IPC: C07D243/10

CPC classification number: C07D243/10

Abstract: The invention provides compounds of Formula (I)





as described herein, along with pharmaceutically acceptable salts, pharmaceutical compositions containing such compounds, and methods to use these compounds, salts and compositions for treating viral infections, particularly infections caused by herpesviruses.

公开(公告)号：US11667613B2

公开(公告)日：2023-06-06

申请号：US17030540

申请日：2020-09-24

Applicant: Novartis AG ,  Gilead Sciences, Inc.

Inventor： Zef Konst ,  Yipin Lu ,  Robert Joseph Moreau ,  Naomi Samadara Rajapaksa ,  Galen Shearn-Nance ,  David Charles Tully ,  Michael Robert Turner ,  Joseph Michael Young ,  Qian Zhao ,  Britton K. Corkey ,  Samuel E. Metobo

IPC: C07D471/04 ,  C07D471/14 ,  A61K31/4162 ,  A61K31/437 ,  A61P31/22 ,  C07D243/10

CPC classification number: C07D243/10

Abstract: The invention provides compounds of Formula (I)




as described herein, along with pharmaceutically acceptable salts, pharmaceutical compositions containing such compounds, and methods to use these compounds, salts and compositions for treating viral infections, particularly infections caused by herpesviruses.

公开(公告)号：US11234977B2

公开(公告)日：2022-02-01

申请号：US16956527

申请日：2018-12-19

Applicant: Novartis AG

Inventor： Jiping Fu ,  Wooseok Han ,  Xianming Jin ,  Keith Bruce Pfister ,  Joseph Michael Young

IPC: C07D471/14 ,  A61K31/4985 ,  A01N43/90 ,  A61P31/20 ,  A61K47/60 ,  A61K38/21 ,  A61K45/06

Abstract: The invention provides compounds of Formula (I) as described herein, along with pharmaceutically acceptable salts, pharmaceutical compositions and pharmaceutical combinations containing such compounds, as well as methods to use these compounds, salts and compositions for treating viral infections, particularly infections caused by hepatitis B virus (HBV), and for reducing the occurrence of serious conditions associated with HBV.

公开(公告)号：US10093673B2

公开(公告)日：2018-10-09

申请号：US15782722

申请日：2017-10-12

Applicant: Novartis AG

Inventor： Jiping Fu ,  Xianming Jin ,  Patrick Lee ,  Peichao Lu ,  Joseph Michael Young

IPC: C07D491/147 ,  C07D471/14 ,  A61K31/4375 ,  C07D217/08 ,  C07D491/14

Abstract: The invention provides compounds of Formula (I) as described herein, along with pharmaceutically acceptable salts, pharmaceutical compositions containing such compounds, and methods to use these compounds, salts and compositions for treating viral infections, particularly infections caused by hepatitis B virus, and reducing the occurrence of serious conditions associated with HBV.