公开(公告)号：US11434192B2

公开(公告)日：2022-09-06

申请号：US16452452

申请日：2019-06-25

Applicant: Novartis AG

Inventor： Florian Karl Kleinbeck-Riniker ,  Benjamin Martin ,  Gerhard Penn ,  Francesco Venturoni ,  Thierry Schlama ,  Thomas Ruch ,  Thomas Allmendinger ,  Bernhard Wietfeld ,  Paolo Filipponi

IPC: C07C59/84 ,  C07C67/035 ,  C07C213/08 ,  C07C69/738 ,  C07C313/06 ,  C07C229/34 ,  C07D265/02 ,  C07D207/36 ,  C07C251/40 ,  C07C251/66 ,  C07C51/373

Abstract: The present invention relates to a new chemical synthesis, intermediates and catalysts useful for the preparation of the neprilysin (NEP) inhibitor sacubitril. It further relates to new intermediate compounds and their use for said new chemical synthesis route.

公开(公告)号：US10377697B2

公开(公告)日：2019-08-13

申请号：US15780957

申请日：2016-12-08

Applicant: Novartis AG

Inventor： Florian Karl Kleinbeck-Riniker ,  Benjamin Martin ,  Gerhard Penn ,  Francesco Venturoni ,  Thierry Schlama ,  Thomas Ruch ,  Thomas Allmendinger ,  Bernhard Wietfeld ,  Paolo Filipponi

IPC: C07C51/373 ,  C07C69/738 ,  C07C313/06 ,  C07C229/34 ,  C07D265/02 ,  C07D207/36 ,  C07C251/40 ,  C07C251/66 ,  C07C59/84 ,  C07C67/035

Abstract: The present invention relates to a new chemical synthesis, intermediates and catalysts useful for the preparation of the neprilysin (NEP) inhibitor sacubitril. It further relates to new intermediate compounds and their use for said new chemical synthesis route.