公开(公告)号：US20210269416A1

公开(公告)日：2021-09-02

申请号：US17260393

申请日：2019-07-15

Applicant: NOVARTIS AG

Inventor： Peng FU ,  Yu GAI ,  Feng GAO ,  Weiyong KONG ,  Yadong LU ,  Zhongcheng MIN ,  Shaofeng RONG ,  Chutian SHU ,  Can WANG ,  Ruidong WANG ,  Jibin ZHAO ,  Xianglin ZHAO ,  Yi ZHAO ,  Jianguang ZHOU ,  Benjamin MARTIN

IPC: C07D401/06 ,  C07D211/74 ,  C07D209/04

Abstract: The present invention relates to a method of synthesizing a compound of formula (I) also referred to as 4-((2S,4S)-(4-ethoxy-1-((5-methoxy-7-methyl-1/-/-indol-4-yl)methyl)piperidin-2-yl))benzoic acid, or a pharmaceutically acceptable salt thereof, and/or intermediates thereof, their use as pharmaceuticals and pharmaceutical compositions and the use of intermediates for preparing a compound of formula (I), or a pharmaceutically acceptable salt thereof.

公开(公告)号：US20190076412A1

公开(公告)日：2019-03-14

申请号：US16190087

申请日：2018-11-13

Applicant: NOVARTIS AG

Inventor： Nicole BUSCHMANN ,  Robin Alec FAIRHURST ,  Pascal FURET ,  Thomas KNÖPFEL ,  Catherine LEBLANC ,  Lv LIAO ,  Robert MAH ,  Pierre NIMSGERN ,  Sebastien RIPOCHE ,  Jing XIONG ,  Bo HAN ,  Can WANG ,  Xianglin ZHAO

IPC: A61K31/4375 ,  A61K31/4545 ,  A61P35/00 ,  A61K31/55 ,  A61K31/496

Abstract: The present invention relates to therapeutic uses of compounds of formula (1) or a pharmaceutically acceptable salt thereof.

公开(公告)号：US20190231760A1

公开(公告)日：2019-08-01

申请号：US16289612

申请日：2019-02-28

Applicant: NOVARTIS AG

Inventor： Nicole BUSCHMANN ,  Robin Alec FAIRHURST ,  Pascal FURET ,  Diana GRAUS PORTA ,  Carolina HAEFLIGER ,  Bo HAN ,  Thomas KNOPFEL ,  Catherine LEBLANC ,  Lv LIAO ,  Robert MAH ,  Masato MURAKAMI ,  Pierre NIMSGERN ,  Michael PALMER ,  Dale PORTER ,  Sebastien RIPOCHE ,  Can WANG ,  Youzhen WANG ,  Andreas WEISS ,  Jing XIONG ,  Xianglin ZHAO

IPC: A61K31/4375 ,  A61P35/00 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/55

Abstract: The present invention relates to therapeutic uses of compounds of formula (I) or a pharmaceutically acceptable salt thereof

公开(公告)号：US20220169630A1

公开(公告)日：2022-06-02

申请号：US17546284

申请日：2021-12-09

Applicant: NOVARTIS AG

Inventor： Peng FU ,  Yu GAI ,  Feng GAO ,  Weiyong KONG ,  Yadong LU ,  Zhongcheng MIN ,  Shaofeng RONG ,  Chutian SHU ,  Can WANG ,  Ruidong WANG ,  Jibin ZHAO ,  Xianglin ZHAO ,  Yi ZHAO ,  Jianguang ZHOU ,  Benjamin MARTIN

IPC: C07D401/06 ,  C07D209/04 ,  C07D211/74

Abstract: The present invention relates to a method of synthesizing a compound of formula (I) also referred to as 4-(((2S,4S)-(4-ethoxy-1-(((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl))benzoic acid, or a pharmaceutically acceptable salt thereof, and/or intermediates thereof, their use as pharmaceuticals and pharmaceutical compositions and the use of intermediates for preparing a compound of formula (I), or a pharmaceutically acceptable salt thereof.

公开(公告)号：US20180185341A1

公开(公告)日：2018-07-05

申请号：US15516443

申请日：2015-10-02

Applicant: Novartis AG

Inventor： Nicole BUSCHMANN ,  Robin Alec FAIRHURST ,  Pascal FURET ,  Diana GRAUS PORTA ,  Carolina HAEFLIGER ,  Bo HAN ,  Thomas KNÖPFEL ,  Catherine LEBLANC ,  Lv LIAO ,  Robert MAH ,  Masato MURAKAMI ,  Pierre NIMSGERN ,  Michael PALMER ,  Dale PORTER ,  Sebastien RIPOCHE ,  Can WANG ,  Youzhen WANG ,  Andreas WEISS ,  Jing XIONG ,  Xianglin ZHAO

IPC: A61K31/4375 ,  A61K31/496 ,  A61P35/00

CPC classification number: A61K31/4375 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/55 ,  A61P35/00

Abstract: The present invention relates to therapeutic uses of compounds of formula (I) or a pharmaceutically acceptable salt thereof