公开(公告)号：US10975120B2

公开(公告)日：2021-04-13

申请号：US16204557

申请日：2018-11-29

Applicant: Novartis AG

Inventor： Aimee Richardson Usera ,  Zachary Hayes Robinson ,  Jennifer Stroka Cobb

IPC: C07K5/103 ,  C07K5/083 ,  C07K5/062 ,  A61K49/00 ,  C07C271/22 ,  C07C317/28 ,  C07K1/13 ,  C07K5/072 ,  A61K47/64 ,  C07D229/02 ,  C07D257/08 ,  C07D209/42 ,  C07K7/02 ,  A61K38/06 ,  A61K38/05 ,  A61K38/07 ,  A61K38/00

Abstract: The present invention relates to methods and reagents for use in site-selective modification of proteins having lysine residues with functionalized peptides using a chemoenzymatic microbial transglutaminase-mediated reaction. The functionalized proteins may be used for study or therapeutic uses.

公开(公告)号：US20190300570A1

公开(公告)日：2019-10-03

申请号：US16204557

申请日：2018-11-29

Applicant: Novartis AG

Inventor： Aimee Richardson Usera ,  Zachary Hayes Robinson ,  Jennifer Stroka Cobb

IPC: C07K5/103 ,  C07K5/072 ,  C07C271/22 ,  C07C317/28 ,  C07D229/02 ,  C07D257/08 ,  A61K49/00 ,  A61K47/64 ,  C07K1/13 ,  C07K5/062 ,  C07K5/083

Abstract: The present invention relates to methods and reagents for use in site-selective modification of proteins having lysine residues with functionalized peptides using a chemoenzymatic microbial transglutaminase-mediated reaction. The functionalized proteins may be used for study or therapeutic uses.