公开(公告)号：US20150099280A1

公开(公告)日：2015-04-09

申请号：US14507539

申请日：2014-10-06

Applicant: Novozymes, Inc.

Inventor： Ana Fidantsef ,  Michael Lamsa ,  Brian Gorre-Clancy

IPC: C12N9/42 ,  C12P19/02 ,  C12P19/14

CPC classification number: C12N9/2445 ,  A61K36/062 ,  C12P19/02 ,  C12P19/14 ,  C12Q1/6895 ,  C12Y302/01021

Abstract: The present invention relates to variants of a parent beta-glucosidase, comprising a substitution at one or more positions corresponding to positions 142, 183, 266, and 703 of amino acids 1 to 842 of SEQ ID NO: 2 or corresponding to positions 142, 183, 266, and 705 of amino acids 1 to 844 of SEQ ID NO: 70, wherein the variant has beta-glucosidase activity. The present invention also relates to nucleotide sequences encoding the variant beta-glucosidases and to nucleic acid constructs, vectors, and host cells comprising the nucleotide sequences.

公开(公告)号：US09080165B2

公开(公告)日：2015-07-14

申请号：US14507539

申请日：2014-10-06

Applicant: Novozymes, Inc.

Inventor： Ana Fidantsef ,  Michael Lamsa ,  Brian Gorre-Clancy

IPC: C12P19/20 ,  C12N15/63 ,  C12N9/42 ,  C12P19/14 ,  C12P19/02

CPC classification number: C12N9/2445 ,  A61K36/062 ,  C12P19/02 ,  C12P19/14 ,  C12Q1/6895 ,  C12Y302/01021

Abstract: The present invention relates to variants of a parent beta-glucosidase, comprising a substitution at one or more positions corresponding to positions 142, 183, 266, and 703 of amino acids 1 to 842 of SEQ ID NO: 2 or corresponding to positions 142, 183, 266, and 705 of amino acids 1 to 844 of SEQ ID NO: 70, wherein the variant has beta-glucosidase activity. The present invention also relates to nucleotide sequences encoding the variant beta-glucosidases and to nucleic acid constructs, vectors, and host cells comprising the nucleotide sequences.