FILAMENTOUS FUNGAL EXPRESSION SYSTEM

    公开(公告)号:US20220267783A1

    公开(公告)日:2022-08-25

    申请号:US17630107

    申请日:2020-06-25

    Applicant: Novozymes A/S

    Abstract: The present invention provides recombinant filamentous fungal host cells producing one or more secreted polypeptide of interest, said cells comprising in their genome at least one nucleic acid construct comprising a first polynucleotide encoding a signal peptide operably linked in translational fusion to a second polynucleotide encoding the polypeptide of interest, wherein the first polynucleotide is heterologous to the second polynucleotide, wherein the first polynucleotide is a polynucleotide having at least 70% sequence identity with SEQ ID NO:1 or a polynucleotide encoding a signal peptide having at least 70% sequence identity with SEQ ID NO:2, as well as methods of producing one or more secreted polypeptide of interest.

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