专利检索 ap:("OCEAN UNIVERSITY OF CHINA") AND inv:"Cuiyao Li" 第 1 页

1.

发明授权
Injectable photothermal hydrogel based on melanin, preparation method, and application thereof 有权

公开(公告)号：US12102682B1

公开(公告)日：2024-10-01

申请号：US18593842

申请日：2024-03-01

申请人： OCEAN UNIVERSITY OF CHINA

发明人： Jing Chang , Lili Guo , Lan Guo , Jishang Sun , Cuiyao Li , Baoqin Han

IPC分类号： A61K41/00 , A61K9/00 , A61K31/704 , A61K47/10 , A61K47/22 , A61K47/36

CPC分类号： A61K41/0057 , A61K9/0019 , A61K31/704 , A61K47/10 , A61K47/22 , A61K47/36

摘要： Embodiments of the present disclosure provide an injectable photothermal hydrogel based on melanin and a preparation method and an application thereof. The injectable photothermal hydrogel is a hydroxypropyl chitosan/bis-amino polyethylene glycol modified melanin nanoparticles (HPCS/MP) hydrogel. The HPCS/MP hydrogel is prepared by mixing bis-amino polyethylene glycol modified melanin nanoparticles (MP) with hydroxypropyl chitosan (HPCS). The MP is synthesized by an amidation reaction of the melanin and the bis-amino PEG. A ratio of a volume of an MP solution to a volume of an HPCS solution in the HPCS/MP hydrogel is 4:6. A concentration of the MP solution is 20 wt %. A concentration of the HPCS solution is 4 wt %.