公开(公告)号：US12110497B2

公开(公告)日：2024-10-08

申请号：US16997231

申请日：2020-08-19

申请人： Ocean University of China

发明人： Huarong Guo ,  Mengxi Wu

IPC分类号： C12N15/86 ,  C12N7/00

CPC分类号： C12N15/86 ,  C12N7/00 ,  C12N2710/14043 ,  C12N2800/105

摘要： The present invention relates to a pseudotyped insect baculovirus gene transfer system and a virus for shrimps, and a construction method and use thereof. The present invention belongs to the technical field of genetic engineering. The pseudotyped insect baculovirus gene transfer system for shrimps disclosed in the present invention includes a Bac-to-Bac insect baculovirus expression system, an expression plasmid carrying shrimp virus envelope protein gene and an insect packaging cell. The present invention can achieve stable and efficient transfer and expression of a foreign gene in a shrimp tissue and cell.

公开(公告)号：US20240327596A1

公开(公告)日：2024-10-03

申请号：US18524186

申请日：2023-11-30

申请人： Ocean University of China

发明人： Hongzhi CUI ,  Ruiqi XU ,  Na WEI ,  Minggang ZHAO ,  Aiping WANG ,  Jun ZHAO

IPC分类号： C08J9/28 ,  B23K26/0622 ,  B23K26/382 ,  B23K26/402 ,  C02F1/14 ,  C08J3/075 ,  C08J3/21 ,  C08J9/36 ,  C08K3/34 ,  C08L5/12 ,  F24S70/16

CPC分类号： C08J9/283 ,  B23K26/0622 ,  B23K26/389 ,  B23K26/402 ,  C02F1/14 ,  C08J3/075 ,  C08J3/212 ,  C08J9/36 ,  C08K3/34 ,  C08L5/12 ,  F24S70/16 ,  C02F2103/08 ,  C08J2201/0484 ,  C08J2205/026 ,  C08J2205/04 ,  C08J2305/12 ,  C08J2429/04 ,  C08K2201/001 ,  C08K2201/011 ,  C08L2203/14 ,  C08L2312/00

摘要： Disclosed are an aerogel with a hierarchical pore structure formed using a pulsed laser technology, and a preparation method and use thereof. In the preparation method, a nano silicon-containing inorganic material as a freezing element, a biomass polymer as a cross-linking agent, and deionized water as a solvent are mixed and a resulting mixture is left to stand and gelatinized to obtain a hydrogel; the hydrogel is frozen to form ice crystals therein, and the ice crystals are removed by freeze-drying to obtain a micron-nano porous aerogel; the micron-nano porous aerogel is subjected to customized millimeter-scale punching using a pulsed laser to obtain an aerogel with a millimeter-micron-nano hierarchical pore structure.

公开(公告)号：US20240327418A1

公开(公告)日：2024-10-03

申请号：US18293840

申请日：2022-08-01

申请人： OCEAN UNIVERSITY OF CHINA ,  QINGDAO HIGENE BIOPHARMACEUTICAL CO., LTD ,  MARINE BIOMEDICAL RESEARCH INSTITUTE OF QINGDAO CO., LTD

发明人： Xiaoyang LI ,  Zhongren ZHOU ,  Yuqi JIANG ,  Kairui YUE ,  Wenfang XU

IPC分类号： C07D491/048 ,  A61K31/343 ,  A61K31/381 ,  A61K31/404 ,  A61K31/4355 ,  A61K31/4365 ,  A61K31/437 ,  A61K31/4406 ,  A61K31/4439 ,  A61K31/655 ,  A61P35/00 ,  A61P35/02 ,  C07C247/12 ,  C07D209/42 ,  C07D213/40 ,  C07D213/56 ,  C07D307/85 ,  C07D333/70 ,  C07D401/04 ,  C07D471/04 ,  C07D495/04

CPC分类号： C07D491/048 ,  A61K31/343 ,  A61K31/381 ,  A61K31/404 ,  A61K31/4355 ,  A61K31/4365 ,  A61K31/437 ,  A61K31/4406 ,  A61K31/4439 ,  A61K31/655 ,  A61P35/00 ,  A61P35/02 ,  C07C247/12 ,  C07D209/42 ,  C07D213/40 ,  C07D213/56 ,  C07D307/85 ,  C07D333/70 ,  C07D401/04 ,  C07D471/04 ,  C07D495/04

摘要： A compound targeting HDAC and NAD synthesis and a pharmaceutically acceptable salt, hydrate, deuterate, isomer or prodrug thereof, as well as preparation and application thereof. Specifically, a compound shown in structural general formula (I) and a pharmaceutically acceptable salt, hydrate, deuterate, isomer or prodrug thereof are provided. The compound of the structural general formula (I) is a multi-target inhibitor, targeting HDAC and NAD targets, and exhibiting significant HDAC inhibitory activity, while representative compounds exhibit certain NAD inhibitory activity.


Ring E-B-L-C (O)—(NH)r-R   (General formula I)

公开(公告)号：US12102682B1

公开(公告)日：2024-10-01

申请号：US18593842

申请日：2024-03-01

申请人： OCEAN UNIVERSITY OF CHINA

发明人： Jing Chang ,  Lili Guo ,  Lan Guo ,  Jishang Sun ,  Cuiyao Li ,  Baoqin Han

IPC分类号： A61K41/00 ,  A61K9/00 ,  A61K31/704 ,  A61K47/10 ,  A61K47/22 ,  A61K47/36

CPC分类号： A61K41/0057 ,  A61K9/0019 ,  A61K31/704 ,  A61K47/10 ,  A61K47/22 ,  A61K47/36

摘要： Embodiments of the present disclosure provide an injectable photothermal hydrogel based on melanin and a preparation method and an application thereof. The injectable photothermal hydrogel is a hydroxypropyl chitosan/bis-amino polyethylene glycol modified melanin nanoparticles (HPCS/MP) hydrogel. The HPCS/MP hydrogel is prepared by mixing bis-amino polyethylene glycol modified melanin nanoparticles (MP) with hydroxypropyl chitosan (HPCS). The MP is synthesized by an amidation reaction of the melanin and the bis-amino PEG. A ratio of a volume of an MP solution to a volume of an HPCS solution in the HPCS/MP hydrogel is 4:6. A concentration of the MP solution is 20 wt %. A concentration of the HPCS solution is 4 wt %.

公开(公告)号：US20240317825A1

公开(公告)日：2024-09-26

申请号：US18607763

申请日：2024-03-18

申请人： OCEAN UNIVERSITY OF CHINA

发明人： QINGFEI LI ,  QINGHUI AI

IPC分类号： C07K14/46 ,  A61K38/00 ,  A61P31/04 ,  A61P37/04

CPC分类号： C07K14/461 ,  A61P31/04 ,  A61P37/04 ,  A61K38/00

摘要： A fish-derived peptidoglycan recognition protein mutant and an application thereof are provided. An amino acid sequence of the mutant is shown in SEQ ID NO.1, a nucleotide sequence of the mutant is shown in SEQ ID NO.2. The present disclosure provides the preparation method for the mutant with a broad-spectrum antibacterial activity and robust inhibitory effects on both Gram-positive and Gram-negative bacteria. Compared with the wild-type LcPGRP5 protein, the mutant protein demonstrates a stronger ability to inhibit the activity against Staphylococcus aureus and enhance the phagocytic ability of fish macrophages.

公开(公告)号：US12061304B2

公开(公告)日：2024-08-13

申请号：US17689928

申请日：2022-03-08

申请人： OCEAN UNIVERSITY OF CHINA

发明人： Yonggang Jia ,  Zhihan Fan ,  Chunsheng Ji ,  Xiaoshuai Song ,  Hailong Shan

IPC分类号： G01V11/00 ,  E21C39/00 ,  G01V1/38 ,  G01V3/08 ,  G01V8/02 ,  B63B27/10 ,  E21C50/00

CPC分类号： G01V11/002 ,  E21C39/00 ,  G01V1/3852 ,  G01V3/082 ,  G01V8/02 ,  B63B27/10 ,  E21C50/00

摘要： A device for monitoring deep-sea sediment environment in mining polymetallic nodules is provided. The monitoring system includes: acoustic Doppler flow profilers, a self-potential probe, a turbidity meter and an underwater camera. The invention can realize long-term in-situ observation of sediment disturbance, and can realize the mechanical recovery of probe rod-type equipment without large-scale mechanical devices, thereby reducing the overall weight of the recovery equipment and increasing the probability of successful equipment recovery. Compared with the existing long-term in-situ observation equipment on the seabed, it is more environmentally friendly, efficient, energy-saving and reliable.

公开(公告)号：US11898842B1

公开(公告)日：2024-02-13

申请号：US18487231

申请日：2023-10-16

申请人： Ocean University of China

发明人： Hua Yang ,  Beibei Mao ,  Xiaoyu Zhu ,  Yuxuan Zheng ,  Wenbo Li ,  Han Zhang

IPC分类号： G01C13/00

CPC分类号： G01C13/002

摘要： It is provided a method and system for calculating a turbulent mixing intensity, a computer device and a storage medium. The method comprises: performing denoising preprocess on ocean spatiotemporal coupled shear profile data information obtained by a turbulence profiler; constructing a multi-layer turbulent mixing network with topological attributes, where the network includes nodes and connecting edges; and each node is formed by fusion of four physical properties: time series, scale data, energy local intermittency measure and phase; recognizing a cross-scale transfer process of the turbulent energy according to a presence state of the connecting edges in the network; and performing parametric calculation of the turbulent mixing intensity according to the topological attributes of the multi-layer turbulent mixing network. According to the method, quantitative calculation of a turbulent energy transport intensity in an observation area of a full ocean depth profile is implemented.

公开(公告)号：US20230375725A1

公开(公告)日：2023-11-23

申请号：US17868889

申请日：2022-07-20

申请人： First Institute of Oceanography, Ministry of Natural Resources ,  Ocean University of China ,  Shandong Marine Resource and Environment Research Institute

发明人： Guangquan Chen ,  Wen Liu ,  Shibin Zhao ,  Chunqian Li ,  Jinjia Guo ,  Yancheng Wang ,  Bochao Xu ,  Xiaofei Yin ,  Shan Sun

IPC分类号： G01T1/185 ,  G01T1/167 ,  G01N33/24

CPC分类号： G01T1/185 ,  G01T1/167 ,  G01N33/24 ,  G01N2033/0093

摘要： Disclosed is a method for determining 224Ra in a sediment by using a pulse ionization chamber emanometer, which belongs to the technical field of analysis and measurement. A pulse ionization chamber emanometer (PIC), a new emanometer, is used. Based on the half-life characteristics of different radon isotopes, one can separate the 220Rn activity from the total counts by dual counting. The resulting 220Rn measurement then can be used to determine the 224Ra activity in sediment according to the principle of secular radioactive equilibrium.

公开(公告)号：US20230333279A1

公开(公告)日：2023-10-19

申请号：US18301258

申请日：2023-04-17

申请人： Ocean University of China

发明人： Fei Sha ,  Hao Kong ,  Tao Liu ,  Rui Fan ,  Mingshuai Xi ,  Shijiu Gu ,  Meng Bu

IPC分类号： G01V99/00

CPC分类号： G01V99/005 ,  E21D11/10

摘要： This invention discloses a model test apparatus and method for shield post-wall grouting and tube sheet uplift under high water pressure conditions, comprising main body box, tension apparatus, shield system, grouting system, ground stress loading system, water injection system, and monitoring system. The main body box comprises the shield shell system and model soil inside. The ground stress loading system and water injection system realize the simulation of the complex underground soil and muddy water environment by applying stress and water pressure to the model soil inside the main box. While the tension apparatus makes the shield shell moving forward, the grouting system injects slurry into the gap between the shield shell and the tube sheet. The integrated model test of visual shield grouting and tube sheet uplift, the real-time multi-physical field responses, and the longitudinal deformation mechanism have been realized and revealed under high water pressure conditions.

公开(公告)号：US11768976B2

公开(公告)日：2023-09-26

申请号：US17453741

申请日：2021-11-05

申请人： China University of Petroleum (East China) ,  Ocean University of China ,  Beihang University

发明人： Baoping Cai ,  Yonghong Liu ,  Xiaoyan Shao ,  Guijie Liu ,  Qiang Feng ,  Qilin Wu ,  Weifeng Ge ,  Xincheng Li ,  Qibing Wu ,  Xiaolu Wu ,  Rui He ,  Zhexian Zou ,  Honghui Wang ,  Hongyan Fan

IPC分类号： G06F30/17 ,  E21B33/035 ,  G06F17/16 ,  G06F111/08

CPC分类号： G06F30/17 ,  E21B33/035 ,  G06F17/16 ,  E21B2200/20 ,  G06F2111/08

摘要： The present disclosure belongs to the field of petroleum engineering, and specifically relates to a subsea Christmas tree re-prediction method integrating Kalman filter and Bayesian network. The subsea Christmas tree re-prediction method integrating Kalman filter and Bayesian network includes three steps: digital twin model establishment, degradation process re-prediction model establishment, and remaining useful life calculation model establishment. The subsea Christmas tree re-prediction system integrating Kalman filter and Bayesian network includes a subsea distribution unit information acquisition subsystem mounted on an subsea distribution unit, a subsea control module information acquisition subsystem mounted on a subsea control module, a subsea valve bank information acquisition subsystem mounted on a subsea valve bank, a wellhead mechanical module information acquisition subsystem mounted on a wellhead mechanical module, a subsea environmental information acquisition module mounted on a subsea control module, and a subsea Christmas tree digital twin subsystem mounted in an overwater control station.