公开(公告)号：US20160176979A1

公开(公告)日：2016-06-23

申请号：US14907368

申请日：2014-07-23

Applicant: Ohio State Innovation Foundation

Inventor： Thomas J. Magliery ,  Brandon J. Sullivan ,  Heather C. Allen ,  Edward W. Martin ,  Charles L. Hitchcock ,  E. David Alten ,  Nicholas E. Long

IPC: C07K16/30 ,  A61N5/10 ,  A61K45/06 ,  A61K51/10 ,  A61K47/48

CPC classification number: C07K16/3076 ,  A61K39/395 ,  A61K45/06 ,  A61K47/6851 ,  A61K51/1045 ,  A61N5/10 ,  C07K16/3092 ,  C07K2317/622 ,  C07K2317/92 ,  C07K2317/94 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/21 ,  C12N5/0693 ,  C12N5/10 ,  C12N15/62 ,  C12N15/66 ,  C12N15/86 ,  C12N2800/00 ,  G01N2800/00

Abstract: Disclosed herein are methods and compositions related to single chain antibody fragments which specifically bind sialyl-Tn epitope of tumor-associated glycoprotein 72 (TAG-72).

Abstract translation: 本文公开了与特异性结合肿瘤相关糖蛋白72（TAG-72）的唾液酸-Tn表位的单链抗体片段相关的方法和组合物。

公开(公告)号：US10919979B2

公开(公告)日：2021-02-16

申请号：US15664425

申请日：2017-07-31

Applicant: Ohio State Innovation Foundation

Inventor： Thomas J. Magliery ,  Brandon J. Sullivan ,  Heather C. Allen ,  Edward W. Martin ,  Charles L. Hitchcock ,  E. David Alten ,  Nicholas E. Long

IPC: C07K16/30 ,  A61K39/395 ,  C12N5/09 ,  A61K51/10 ,  A61K47/68 ,  A61K45/06 ,  A61N5/10 ,  C12N15/86 ,  C12N15/66 ,  C12N15/62 ,  C12N5/10

Abstract: Disclosed herein are methods and compositions related to single chain antibody fragments which specifically bind sialyl-Tn epitope of tumor-associated glycoprotein 72 (TAG-72).

公开(公告)号：US11787872B2

公开(公告)日：2023-10-17

申请号：US16694052

申请日：2019-11-25

Applicant: OHIO STATE INNOVATION FOUNDATION

Inventor： Thomas J. Magliery ,  Brandon J. Sullivan ,  Nicholas E. Long

IPC: C07K16/30 ,  A61K51/10 ,  A61K39/395 ,  G01N33/574 ,  A61K47/60 ,  A61K39/00

CPC classification number: C07K16/3092 ,  A61K39/39558 ,  A61K39/39591 ,  A61K47/60 ,  A61K51/1045 ,  A61K51/1093 ,  G01N33/57492 ,  A61K2039/505 ,  C07K2317/14 ,  C07K2317/24 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94 ,  G01N2333/4728

Abstract: Disclosed herein are methods and compositions related to antibody fragments which specifically bind sialyl-Tn epitope of tumor-associated glycoprotein 72 (TAG-72).

公开(公告)号：US20200255538A1

公开(公告)日：2020-08-13

申请号：US16694052

申请日：2019-11-25

Applicant: OHIO STATE INNOVATION FOUNDATION

Inventor： Thomas J. Magliery ,  Brandon J. Sullivan ,  Nicholas E. Long

IPC: C07K16/30 ,  A61K51/10 ,  G01N33/574 ,  A61K39/395 ,  A61K47/60

Abstract: Disclosed herein are methods and compositions related to antibody fragments which specifically bind sialyl-Tn epitope of tumor-associated glycoprotein 72 (TAG-72).

公开(公告)号：US12227558B2

公开(公告)日：2025-02-18

申请号：US18167121

申请日：2023-02-10

Applicant: Ohio State Innovation Foundation

Inventor： Thomas J. Magliery ,  Mikhail M. Dikov ,  David Carbone ,  Nicholas Long ,  Brandon Sullivan ,  Elena Tchekneva

IPC: A61K38/00 ,  A61P35/00 ,  A61P37/06 ,  C07K14/705

Abstract: Described herein are Notch-modulating peptides (including monomers and multimers) capable of increasing or decreasing an immune response in a subject, compositions comprising the peptides, and methods of use thereof.

公开(公告)号：US20240166762A1

公开(公告)日：2024-05-23

申请号：US18447109

申请日：2023-08-09

Applicant: OHIO STATE INNOVATION FOUNDATION

Inventor： Thomas J. Magliery ,  Brandon J. Sullivan ,  Nicholas E. Long

IPC: C07K16/30 ,  A61K39/395 ,  A61K47/60 ,  A61K51/10 ,  G01N33/574

CPC classification number: C07K16/3092 ,  A61K39/39558 ,  A61K39/39591 ,  A61K47/60 ,  A61K51/1045 ,  A61K51/1093 ,  G01N33/57492 ,  A61K2039/505

Abstract: Antibodies recognizing TAG-72 provide a novel approach for the imaging, detection, and treatment of cancer. These methods are made possible by using antibody fragments that bind specifically to the sialyl-Tn surface adhesin of TAG-72. Antibody fragment derivatives are advantageously useful over other antibody and antibody fragments known in the art because they are easy to express in large quantities, can penetrate tissues easily and lack the constant domains that promote often unwanted and usually superfluous effector functions.

公开(公告)号：US20170218081A1

公开(公告)日：2017-08-03

申请号：US15328222

申请日：2015-07-23

Applicant: OHIO STATE INNOVATION FOUNDATION

Inventor： Thomas J. Magliery ,  Brandon J. Sullivan ,  Nicholas E. Long

IPC: C07K16/30 ,  A61K39/395 ,  A61K51/10

CPC classification number: C07K16/3092 ,  A61K39/39558 ,  A61K39/39591 ,  A61K47/60 ,  A61K51/1045 ,  A61K51/1093 ,  A61K2039/505 ,  C07K2317/14 ,  C07K2317/24 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94 ,  G01N33/57492 ,  G01N2333/4728

Abstract: Disclosed herein are methods and compositions related to antibody fragments which specifically bind sialyl-Tn epitope of tumor-associated glycoprotein 72 (TAG-72).

公开(公告)号：US09718888B2

公开(公告)日：2017-08-01

申请号：US14907368

申请日：2014-07-23

Applicant: Ohio State Innovation Foundation

Inventor： Thomas J. Magliery ,  Brandon J. Sullivan ,  Heather C. Allen ,  Edward W. Martin ,  Charles L. Hitchcock ,  E. David Alten ,  Nicholas E. Long

IPC: C07K16/30 ,  A61K51/10 ,  C12N15/62 ,  C12N15/70 ,  C12N15/79 ,  C12N1/21 ,  C12N15/13 ,  A61K39/395 ,  G01N33/563 ,  G01N33/574 ,  G01N33/573 ,  G01N33/58 ,  C12N5/09 ,  A61K45/06 ,  A61K47/48 ,  A61N5/10 ,  C12N15/86 ,  C12N15/66 ,  C12N5/10

CPC classification number: C07K16/3076 ,  A61K39/395 ,  A61K45/06 ,  A61K47/6851 ,  A61K51/1045 ,  A61N5/10 ,  C07K16/3092 ,  C07K2317/622 ,  C07K2317/92 ,  C07K2317/94 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/21 ,  C12N5/0693 ,  C12N5/10 ,  C12N15/62 ,  C12N15/66 ,  C12N15/86 ,  C12N2800/00 ,  G01N2800/00

Abstract: Disclosed herein are methods and compositions related to single chain antibody fragments which specifically bind sialyl-Tn epitope of tumor-associated glycoprotein 72 (TAG-72).

公开(公告)号：US11613567B2

公开(公告)日：2023-03-28

申请号：US16496163

申请日：2018-03-26

Applicant: Ohio State Innovation Foundation

Inventor： Thomas J. Magliery ,  Mikhail M. Dikov ,  David Carbone ,  Nicholas Long ,  Brandon Sullivan ,  Elena Tchekneva

IPC: A61K38/00 ,  C07K14/705 ,  A61P37/06 ,  A61P35/00

Abstract: Described herein are Notch-modulating peptides (including monomers and multimers) capable of increasing or decreasing an immune response in a subject, compositions comprising the peptides, and methods of use thereof.

公开(公告)号：US20180037663A1

公开(公告)日：2018-02-08

申请号：US15664425

申请日：2017-07-31

Applicant: Ohio State Innovation Foundation

Inventor： Thomas J. Magliery ,  Brandon J. Sullivan ,  Heather C. Allen ,  Edward W. Martin ,  Charles L. Hitchcock ,  E. David Alten ,  Nicholas E. Long

IPC: C07K16/30 ,  A61K45/06 ,  A61K51/10 ,  C12N5/09 ,  A61K39/395 ,  A61N5/10 ,  C12N15/86 ,  C12N5/10 ,  C12N15/62 ,  C12N15/66

CPC classification number: C07K16/3076 ,  A61K39/395 ,  A61K45/06 ,  A61K47/6851 ,  A61K51/1045 ,  A61N5/10 ,  C07K16/3092 ,  C07K2317/622 ,  C07K2317/92 ,  C07K2317/94 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/21 ,  C12N5/0693 ,  C12N5/10 ,  C12N15/62 ,  C12N15/66 ,  C12N15/86 ,  C12N2800/00 ,  G01N2800/00

Abstract: Disclosed herein are methods and compositions related to single chain antibody fragments which specifically bind sialyl-Tn epitope of tumor-associated glycoprotein 72 (TAG-72).