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    METHODS AND COMPOSITIONS COMPRISING TAU OLIGOMERS
    1.
    发明申请
    METHODS AND COMPOSITIONS COMPRISING TAU OLIGOMERS 有权

    公开(公告)号：US20210395319A1

    公开(公告)日：2021-12-23

    申请号：US17461862

    申请日：2021-08-30

    申请人： OLIGOMERIX, INC.

    发明人： James G. Moe ,  Eliot J. Davidowitz

    IPC分类号： C07K14/47 ,  C12N9/64 ,  A61K38/17

    摘要： Tau protein has a causative role in Alzheimer's disease and multiple other neurodegenerative disorders exhibiting tau histopathology collectively termed tauopathies. The primary function of tau protein is to facilitate assembly and maintenance of microtubules in neuronal axons. In the disease process tau protein becomes modified, loses its affinity to microtubules and accumulates in the cell body where it forms aggregates. The large neurofibrillary tangles formed from tau protein assembled into filaments were thought to be the pathological structure of tau. However, more recent work indicates that smaller, soluble oligomeric forms of tau are best associated with neuron loss and memory impairment. Here, novel compositions of tau oligomers and novel mechanisms for tau oligomer nucleation, extension and termination are taught. Methods for producing and purifying these structures for the development of small molecule and immunotherapeutics as well as antibodies for biomarkers of neurodegenerative diseases are taught.

    METHODS AND COMPOSITIONS COMPRISING TAU OLIGOMERS
    2.
    发明申请
    METHODS AND COMPOSITIONS COMPRISING TAU OLIGOMERS 审中-公开
    包含TAU OLIGOMERS的方法和组合物

    公开(公告)号：US20170015717A1

    公开(公告)日：2017-01-19

    申请号：US15285181

    申请日：2016-10-04

    申请人： OLIGOMERIX, INC.

    发明人： JAMES G. MOE ,  Eliot J. Davidowitz

    IPC分类号： C07K14/47 ,  A61K38/17

    CPC分类号： C07K14/47 ,  A61K38/1709 ,  C12N9/6421

    摘要： Tau protein has a causative role in Alzheimer's disease and multiple other neurodegenerative disorders exhibiting tau histopathology collectively termed tauopathies. The primary function of tau protein is to facilitate assembly and maintenance of microtubules in neuronal axons. In the disease process tau protein becomes modified, loses its affinity to microtubules and accumulates in the cell body where it forms aggregates. The large neurofibrillary tangles formed from tau protein assembled into filaments were thought to be the pathological structure of tau. However, more recent work indicates that smaller, soluble oligomeric forms of tau are best associated with neuron loss and memory impairment. Here, novel compositions of tau oligomers and novel mechanisms for tau oligomer nucleation, extension and termination are taught. Methods for producing and purifying these structures for the development of small molecule and immunotherapeutics as well as antibodies for biomarkers of neurodegenerative diseases are taught.

    摘要翻译： Tau蛋白在阿尔茨海默病和多种其他神经退行性疾病中起着重要的作用，其表现为组织病理学统称为tau蛋白病。 tau蛋白的主要功能是促进神经元轴突中微管的组装和维持。 在疾病过程中，tau蛋白被修饰，丧失其对微管的亲和力，并在细胞体积聚，形成聚集体。 由tau蛋白形成的大的神经原纤维缠结组织成长丝被认为是tau的病理结构。 然而，最近的工作表明，较小的可溶性寡聚体形式的tau最好与神经元损失和记忆障碍有关。 在这里，教导了tau寡聚体的新型组合物和用于tau低聚物成核，延伸和终止的新机制。 制备和纯化用于开发小分子和免疫治疗剂的这些结构的方法以及用于神经变性疾病的生物标志物的抗体。