公开(公告)号：US20190022012A1

公开(公告)日：2019-01-24

申请号：US15534145

申请日：2015-12-16

Applicant: Omya International AG

Inventor： Jörg Huwyler ,  Maxim Puchkov ,  Tanja Stirnimann ,  Susanna Atria

IPC: A61K9/20 ,  A61K9/16 ,  A61K31/167

Abstract: The present invention relates to a method for producing a pharmaceutical delivery system, the use of a surface-reacted calcium carbonate for improving the friability of a pharmaceutical delivery system as well as for improving the flowability of a pharmaceutical delivery system and a pharmaceutical delivery system obtained by the method.

公开(公告)号：US20180078506A1

公开(公告)日：2018-03-22

申请号：US15554235

申请日：2016-03-15

Applicant: Omya International AG

Inventor： Leonie Wagner-Hattler ,  Maxim Puchkov ,  Jörg Huwyler ,  Tanja Stirnimann ,  Carolina Diaz Quijano ,  Joachim Schoelkopf ,  Patrick A.C. Gane ,  Daniel E. Gerard

IPC: A61K9/16 ,  A61K9/20 ,  C01F11/18

CPC classification number: A61K9/1682 ,  A61K9/1605 ,  A61K9/1664 ,  A61K9/2068 ,  A61K9/2095 ,  C01F11/185 ,  C01P2006/10 ,  C01P2006/12 ,  C01P2006/14

Abstract: The present invention provides for method of improving flowability and loose bulk density of functionalized natural- and/or synthetic calcium carbonate comprising material, to the use of such improved material in ready to use granules and thereof produced dispersible dosage forms.

公开(公告)号：US20150283082A1

公开(公告)日：2015-10-08

申请号：US14428052

申请日：2013-10-10

Applicant: OMYA INTERNATIONAL AG

Inventor： Daniel E. Gerard ,  Joachim Schoelkopf ,  Patrick A.C. Gane ,  Tanja Stirnimann ,  Rainer Alles ,  Maxim Puchkov ,  Jörg Huwyler

IPC: A61K9/20 ,  A61K9/00 ,  B29C43/00 ,  A61K31/519 ,  A61K9/46

Abstract: An orally fast disintegrating dosage forms comprising functionalized natural or synthetic calcium carbonate, at least one active ingredient and at least one disintegrant, wherein said functionalized natural or synthetic calcium carbonate is a reaction product of natural or synthetic calcium carbonate with carbon dioxide and one or more acids, wherein the carbon dioxide is formed in situ by the acid treatment and/or is supplied from an external source, and wherein the tablet dissolves in less than 20 seconds when introduced into an aqueous environment.

Abstract translation: 包含官能化天然或合成碳酸钙，至少一种活性成分和至少一种崩解剂的口服快速崩解剂型，其中所述官能化天然或合成碳酸钙是天然或合成碳酸钙与二氧化碳和一种或多种碳酸钙的反应产物 酸，其中二氧化碳通过酸处理原位形成和/或从外部来源供应，并且其中当引入到水性环境中时，片剂在少于20秒内溶解。