公开(公告)号：US09463192B2

公开(公告)日：2016-10-11

申请号：US14768727

申请日：2014-02-18

Applicant: ONO PHARMACEUTICAL CO., LTD.

Inventor： Jun Takeuchi ,  Satoshi Itadani ,  Kazuya Hashimura ,  Masahiro Ikura ,  Masato Higashino ,  Tetsuya Yasuhiro ,  Takeshi Nagaura

IPC: A61K31/506 ,  A61K31/136 ,  A61K31/444 ,  A61K31/519 ,  A61K31/663 ,  A61K31/5377 ,  C07D401/14 ,  C07D401/12 ,  C07D213/75 ,  C07D239/47 ,  C07D471/04 ,  C07D487/04 ,  A61K45/06 ,  C07D405/14 ,  C07D409/14

CPC classification number: A61K31/506 ,  A61K31/136 ,  A61K31/444 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/663 ,  A61K45/06 ,  C07D213/75 ,  C07D239/47 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D471/04 ,  C07D487/04 ,  Y02A50/414

Abstract: The present invention provides a drug containing a compound having Trk-inhibiting activity as an active ingredient in prophylaxis and/or therapy for Trk-related diseases such as pain, pruritus, lower urinary tract dysfunction, asthma, allergic rhinitis, inflammatory bowel disease or Chagas disease. A compound represented by the general formula (I), wherein all symbols represent the same meanings as described in the specification, a salt thereof, an N-oxide thereof, a solvate thereof or a prodrug thereof is useful as a drug component having Trk-inhibiting activity in prophylaxis and/or therapy of diseases such as pain, pruritus, lower urinary tract dysfunction, asthma, allergic rhinitis, inflammatory bowel disease or Chagas disease.

公开(公告)号：US10399959B2

公开(公告)日：2019-09-03

申请号：US15504514

申请日：2015-08-17

Applicant: ONO PHARMACEUTICAL CO., LTD.

Inventor： Jun Takeuchi ,  Satoshi Itadani ,  Masahiro Ikura ,  Masato Higashino ,  Hideomi Kijima ,  Shizuka Ono ,  Tetsuya Yasuhiro ,  Takeshi Nagaura

IPC: C07D401/12 ,  C07D401/14 ,  A61K45/00 ,  A61K31/506 ,  C07C309/04 ,  A61K45/06 ,  C07C309/29 ,  C07C309/30

Abstract: In order to provide a prophylactic and/or therapeutic agent for Trk-related diseases, the present invention provides a compound which has a selective Trk-inhibiting activity and persistently inhibits NGF vascular hyper permeability and does not have a drug interaction and in addition thereto, is excellent in solubility and absorbability against free bases. The compound of the present invention has a selective Trk-inhibiting activity and persistently inhibits NGF vascular hyper permeability and does not have a drug interaction and is excellent in solubility and absorbability against free bases, and is therefore useful as a prophylactic and/or therapeutic agent for Trk-related diseases.

公开(公告)号：US09993479B2

公开(公告)日：2018-06-12

申请号：US15679568

申请日：2017-08-17

Applicant: ONO PHARMACEUTICAL CO., LTD.

Inventor： Jun Takeuchi ,  Satoshi Itadani ,  Kazuya Hashimura ,  Masahiro Ikura ,  Masato Higashino ,  Tetsuya Yasuhiro ,  Takeshi Nagaura

IPC: A61K31/506 ,  A61K31/136 ,  A61K31/444 ,  A61K31/519 ,  A61K31/663 ,  A61K31/5377 ,  A61K45/06 ,  C07D213/75 ,  C07D239/47 ,  C07D401/14 ,  C07D401/12 ,  C07D405/14 ,  C07D409/14 ,  C07D471/04 ,  C07D487/04

CPC classification number: A61K31/506 ,  A61K31/136 ,  A61K31/444 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/663 ,  A61K45/06 ,  C07D213/75 ,  C07D239/47 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D471/04 ,  C07D487/04 ,  Y02A50/414

Abstract: The present invention provides a drug containing a compound having Trk-inhibiting activity as an active ingredient in prophylaxis and/or therapy for Trk-related diseases such as pain, pruritus, lower urinary tract dysfunction, asthma, allergic rhinitis, inflammatory bowel disease or Chagas disease. A compound represented by the general formula (I), wherein all symbols represent the same meanings as described in the specification, a salt thereof, an N-oxide thereof, a solvate thereof or a prodrug thereof is useful as a drug component having Trk-inhibiting activity in prophylaxis and/or therapy of diseases such as pain, pruritus, lower urinary tract dysfunction, asthma, allergic rhinitis, inflammatory bowel disease or Chagas disease.

公开(公告)号：US10765676B2

公开(公告)日：2020-09-08

申请号：US16376518

申请日：2019-04-05

Applicant: ONO PHARMACEUTICAL CO., LTD.

Inventor： Jun Takeuchi ,  Satoshi Itadani ,  Kazuya Hashimura ,  Masahiro Ikura ,  Masato Higashino ,  Tetsuya Yasuhiro ,  Takeshi Nagaura

IPC: A61K31/506 ,  A61K31/444 ,  A61K31/519 ,  A61K31/663 ,  C07D401/14 ,  C07D213/75 ,  C07D401/12 ,  C07D239/47 ,  C07D471/04 ,  C07D487/04 ,  A61P29/00 ,  A61K31/136 ,  A61K31/5377 ,  C07D405/14 ,  C07D409/14 ,  A61K45/06

Abstract: The present invention provides a drug containing a compound having Trk-inhibiting activity as an active ingredient in prophylaxis and/or therapy for Trk-related diseases such as pain, pruritus, lower urinary tract dysfunction, asthma, allergic rhinitis, inflammatory bowel disease or Chagas disease. A compound represented by the general formula (I), wherein all symbols represent the same meanings as described in the specification, a salt thereof, an N-oxide thereof, a solvate thereof or a prodrug thereof is useful as a drug component having Trk-inhibiting activity in prophylaxis and/or therapy of diseases such as pain, pruritus, lower urinary tract dysfunction, asthma, allergic rhinitis, inflammatory bowel disease or Chagas disease.

公开(公告)号：US09763943B2

公开(公告)日：2017-09-19

申请号：US15291700

申请日：2016-10-12

Applicant: ONO PHARMACEUTICAL CO., LTD.

Inventor： Jun Takeuchi ,  Satoshi Itadani ,  Kazuya Hashimura ,  Masahiro Ikura ,  Masato Higashino ,  Tetsuya Yasuhiro ,  Takeshi Nagaura

IPC: A61K31/506 ,  C07D401/14 ,  C07D213/75 ,  C07D401/12 ,  C07D239/47 ,  C07D471/04 ,  C07D487/04 ,  A61K45/06 ,  A61K31/136 ,  A61K31/444 ,  A61K31/519 ,  A61K31/663 ,  A61K31/5377 ,  C07D405/14 ,  C07D409/14

CPC classification number: A61K31/506 ,  A61K31/136 ,  A61K31/444 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/663 ,  A61K45/06 ,  C07D213/75 ,  C07D239/47 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D471/04 ,  C07D487/04 ,  Y02A50/414

Abstract: The present invention provides a drug containing a compound having Trk-inhibiting activity as an active ingredient in prophylaxis and/or therapy for Trk-related diseases such as pain, pruritus, lower urinary tract dysfunction, asthma, allergic rhinitis, inflammatory bowel disease or Chagas disease. A compound represented by the general formula (I), wherein all symbols represent the same meanings as described in the specification, a salt thereof, an N-oxide thereof, a solvate thereof or a prodrug thereof is useful as a drug component having Trk-inhibiting activity in prophylaxis and/or therapy of diseases such as pain, pruritus, lower urinary tract dysfunction, asthma, allergic rhinitis, inflammatory bowel disease or Chagas disease.

公开(公告)号：US10300060B2

公开(公告)日：2019-05-28

申请号：US15975130

申请日：2018-05-09

Applicant: ONO PHARMACEUTICAL CO., LTD.

Inventor： Jun Takeuchi ,  Satoshi Itadani ,  Kazuya Hashimura ,  Masahiro Ikura ,  Masato Higashino ,  Tetsuya Yasuhiro ,  Takeshi Nagaura

IPC: A61K31/506 ,  C07D401/14 ,  C07D213/75 ,  C07D401/12 ,  C07D239/47 ,  C07D471/04 ,  C07D487/04 ,  A61K45/06 ,  A61K31/136 ,  A61K31/444 ,  A61K31/519 ,  A61K31/663 ,  A61K31/5377 ,  C07D405/14 ,  C07D409/14 ,  A61P29/00

Abstract: The present invention provides a drug containing a compound having Trk-inhibiting activity as an active ingredient in prophylaxis and/or therapy for Trk-related diseases such as pain, pruritus, lower urinary tract dysfunction, asthma, allergic rhinitis, inflammatory bowel disease or Chagas disease. A compound represented by the general formula (I), wherein all symbols represent the same meanings as described in the specification, a salt thereof, an N-oxide thereof, a solvate thereof or a prodrug thereof is useful as a drug component having Trk-inhibiting activity in prophylaxis and/or therapy of diseases such as pain, pruritus, lower urinary tract dysfunction, asthma, allergic rhinitis, inflammatory bowel disease or Chagas disease.

公开(公告)号：US09242977B2

公开(公告)日：2016-01-26

申请号：US14397070

申请日：2013-04-25

Applicant: ONO PHARMACEUTICAL CO., LTD.

Inventor： Jun Takeuchi ,  Masahiro Ikura ,  Masato Higashino ,  Maki Iwahashi ,  Kazuya Hashimura

IPC: C07D417/12 ,  A61K31/513 ,  C07D417/14 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/5377 ,  A61K31/55 ,  A61K45/06

CPC classification number: C07D417/14 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/513 ,  A61K31/5377 ,  A61K31/55 ,  A61K45/06 ,  C07D417/12 ,  Y02A50/414

Abstract: An object of the present invention is to provide a drug containing a compound having Trk-inhibiting activity as an active ingredient in prophylaxis and/or therapy of diseases such as pain, pruritus, lower urinary tract dysfunction, asthma, allergic rhinitis, inflammatory bowel disease or Chagas disease. A compound represented by the general formula (I): (wherein all symbols represent the same meanings as described in the specification), a salt thereof, an N-oxide thereof, a solvate thereof or a prodrug thereof is useful as a drug component having Trk-inhibiting activity in prophylaxis and/or therapy of diseases such as pain, pruritus, lower urinary tract dysfunction, asthma, allergic rhinitis, inflammatory bowel disease or Chagas disease.

Abstract translation: 本发明的目的是提供含有具有Trk抑制活性的化合物作为活性成分的药物，用于预防和/或治疗诸如疼痛，瘙痒，下尿路功能障碍，哮喘，过敏性鼻炎，炎症性肠病 或恰加斯病。 由通式（I）表示的化合物：其中所有符号表示与说明书中所述相同的含义，其盐，其N-氧化物，其溶剂合物或其前药可用作具有 预防和/或治疗疾病如疼痛，瘙痒，下尿路功能障碍，哮喘，过敏性鼻炎，炎性肠病或恰加斯病的Trk抑制活性。

公开(公告)号：US09498453B2

公开(公告)日：2016-11-22

申请号：US15173161

申请日：2016-06-03

Applicant: ONO PHARMACEUTICAL CO., LTD.

Inventor： Jun Takeuchi ,  Satoshi Itadani ,  Kazuya Hashimura ,  Masahiro Ikura ,  Masato Higashino ,  Tetsuya Yasuhiro ,  Takeshi Nagaura

IPC: A61K31/136 ,  A61K31/444 ,  A61K31/506 ,  A61K31/519 ,  A61K31/663 ,  A61K31/5377 ,  C07D213/75 ,  C07D401/12 ,  C07D401/14 ,  C07D239/47 ,  C07D471/04 ,  C07D487/04 ,  C07D405/14 ,  C07D409/14 ,  A61K45/06

CPC classification number: A61K31/506 ,  A61K31/136 ,  A61K31/444 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/663 ,  A61K45/06 ,  C07D213/75 ,  C07D239/47 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D471/04 ,  C07D487/04 ,  Y02A50/414

Abstract: The present invention provides a drug containing a compound having Trk-inhibiting activity as an active ingredient in prophylaxis and/or therapy for Trk-related diseases such as pain, pruritus, lower urinary tract dysfunction, asthma, allergic rhinitis, inflammatory bowel disease or Chagas disease. A compound represented by the general formula (I), wherein all symbols represent the same meanings as described in the specification, a salt thereof, an N-oxide thereof, a solvate thereof or a prodrug thereof is useful as a drug component having Trk-inhibiting activity in prophylaxis and/or therapy of diseases such as pain, pruritus, lower urinary tract dysfunction, asthma, allergic rhinitis, inflammatory bowel disease or Chagas disease.

Abstract translation: 本发明提供了含有Trk-抑制活性的化合物作为预防和/或治疗Trk相关疾病如疼痛，瘙痒，下尿路功能障碍，哮喘，过敏性鼻炎，炎性肠病或查加斯的有效成分的药物 疾病。 由通式（I）表示的化合物：其中所有符号表示与说明书中所述相同的含义，其盐，其N-氧化物，其溶剂化物或其前药可用作具有Trk- 抑制预防和/或治疗诸如疼痛，瘙痒，下尿路功能障碍，哮喘，过敏性鼻炎，炎性肠病或恰加斯病等疾病的活性。

公开(公告)号：US20150111865A1

公开(公告)日：2015-04-23

申请号：US14397070

申请日：2013-04-25

Applicant: ONO PHARMACEUTICAL CO., LTD.

Inventor： Jun Takeuchi ,  Masahiro Ikura ,  Masato Higashino ,  Maki Iwahashi ,  Kazuya Hashimura

IPC: C07D417/14 ,  A61K31/444 ,  A61K45/06 ,  C07D417/12 ,  A61K31/4439 ,  A61K31/5377 ,  A61K31/513 ,  A61K31/55

CPC classification number: C07D417/14 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/513 ,  A61K31/5377 ,  A61K31/55 ,  A61K45/06 ,  C07D417/12 ,  Y02A50/414

Abstract: An object of the present invention is to provide a drug containing a compound having Trk-inhibiting activity as an active ingredient in prophylaxis and/or therapy of diseases such as pain, pruritus, lower urinary tract dysfunction, asthma, allergic rhinitis, inflammatory bowel disease or Chagas disease. A compound represented by the general formula (I): (wherein all symbols represent the same meanings as described in the specification), a salt thereof, an N-oxide thereof, a solvate thereof or a prodrug thereof is useful as a drug component having Trk-inhibiting activity in prophylaxis and/or therapy of diseases such as pain, pruritus, lower urinary tract dysfunction, asthma, allergic rhinitis, inflammatory bowel disease or Chagas disease.

Abstract translation: 本发明的目的是提供含有具有Trk抑制活性的化合物作为活性成分的药物，用于预防和/或治疗诸如疼痛，瘙痒，下尿路功能障碍，哮喘，过敏性鼻炎，炎症性肠病 或恰加斯病。 由通式（I）表示的化合物：其中所有符号表示与说明书中所述相同的含义，其盐，其N-氧化物，其溶剂合物或其前药可用作具有 预防和/或治疗疾病如疼痛，瘙痒，下尿路功能障碍，哮喘，过敏性鼻炎，炎性肠病或恰加斯病的Trk抑制活性。