公开(公告)号：US20240342286A1

公开(公告)日：2024-10-17

申请号：US18669670

申请日：2024-05-21

申请人： ORTA DOGU TEKNIK UNIVERSITESI ,  KOC UNIVERSITESI

发明人： Gorkem GUNBAS ,  Safacan KOLEMEN ,  Osman KARAMAN ,  Gizem ATAKAN ,  Toghrul ALMAMMADOV

IPC分类号： A61K41/00 ,  C07F5/02 ,  C07F7/08

CPC分类号： A61K41/0057 ,  C07F5/022 ,  C07F7/0814

摘要： Near-infrared (NIR) absorbing photosensitizers for imaging and treatment of cancer in a photodynamic therapy (PDT) are provided. Specifically, the NIR photosensitizers are mitochondria targeted and water-soluble, and used as a cytotoxic drug in a photodynamic therapy of the cancer. The NIR photosensitizers are activated with wavelengths of light, wherein the light penetrates through a body not just a skin. Hence the NIR photosensitizers aim to transform PDT from being a specialized treatment to a generally applicable one. PDT is almost completely non-invasive compared to current treatment methods.

公开(公告)号：US20210252152A1

公开(公告)日：2021-08-19

申请号：US16973435

申请日：2018-06-25

申请人： ORTA DOGU TEKNIK UNIVERSITESI ,  KOC UNIVERSITESI

发明人： Gorkem GUNBAS ,  Safacan KOLEMEN ,  Osman KARAMAN ,  Gizem ATAKAN ,  Toghrul ALMAMMADOV

IPC分类号： A61K41/00 ,  C07F5/02 ,  C07F7/08

摘要： Near-infrared (NIR) absorbing photosensitizers for imaging and treatment of cancer in a photodynamic therapy (PDT) are provided. Specifically, the NIR photosensitizers are mitochondria targeted and water-soluble, and used as a cytotoxic drug in a photodynamic therapy of the cancer. The NIR photosensitizers are activated with wavelengths of light, wherein the light penetrates through a body not just a skin. Hence the NIR photosensitizers aim to transform PDT from being a specialized treatment to a generally applicable one. PDT is almost completely non-invasive compared to current treatment methods.