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公开(公告)号：US20230414705A1
公开(公告)日：2023-12-28
申请号：US18242406
申请日：2023-09-05
申请人： OrthoTrophix, Inc.
发明人： Yoshinari Kumagai , Dawn McGuire , Meghan Miller , David Rosen
IPC分类号： A61K38/16 , A61K9/00 , A61P19/02 , A61B5/00 , A61B5/055 , A61B6/03 , A61B6/00 , A61B8/08 , A61K38/18
CPC分类号： A61K38/16 , A61K9/0019 , A61P19/02 , A61B5/4504 , A61B5/4848 , A61B5/055 , A61B6/032 , A61B6/505 , A61B8/0875 , A61K38/18
摘要： Compounds, pharmaceutical compositions, and a method of treating hard tissue diseases and disorders are disclosed. The compounds may be a peptide and is structured to bind integrin αvβ3 expressed by osteocytes and by selective binding to the cell surface integrin on hard tissue forming cells regulate three-dimensional bone shape, cartilage formation and repair.
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公开(公告)号：US20200002393A1
公开(公告)日：2020-01-02
申请号：US16006475
申请日：2018-06-12
申请人： ORTHOTROPHIX, INC.
发明人： Yoshinari Kumagai , Dawn McGuire , Meghan Miller , David Rosen
IPC分类号： C07K14/47 , A61K9/00 , A61P19/02 , A61K31/728
摘要： A method of alleviating joint pain in a patient comprising evaluating the patient's joint pain when undergoing motions associated stress to the joint, and injecting the patient with a peptide of SEQ ID No. 1, and thereafter evaluating the patient's joint pain when undergoing the same motion.
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公开(公告)号：US11793857B2
公开(公告)日：2023-10-24
申请号：US17477918
申请日：2021-09-17
申请人： ORTHOTROPHIX, INC.
发明人： Yoshinari Kumagai , Dawn McGuire , Meghan Miller , David Rosen
IPC分类号： A61K38/00 , A61K38/16 , A61K9/00 , A61P19/02 , A61B5/00 , A61B5/055 , A61B6/03 , A61B6/00 , A61B8/08 , A61K38/18
CPC分类号： A61K38/16 , A61B5/055 , A61B5/4504 , A61B5/4848 , A61B6/032 , A61B6/505 , A61B8/0875 , A61K9/0019 , A61K38/18 , A61P19/02
摘要： Compounds, pharmaceutical compositions, and a method of treating hard tissue diseases and disorders are disclosed. The compounds may be a peptide and is structured to bind integrin αvβ3 expressed by osteocytes and by selective binding to the cell surface integrin on hard tissue forming cells regulate three-dimensional bone shape, cartilage formation and repair.
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公开(公告)号：US10849959B2
公开(公告)日：2020-12-01
申请号：US16006638
申请日：2018-06-12
申请人： ORTHOTROPHIX, INC.
发明人： Yoshinari Kumagai , Dawn McGuire , Meghan Miller , David Rosen
IPC分类号： A61K38/16 , A61K38/00 , A61K47/36 , A61K9/19 , A61P19/02 , C07K14/00 , A61K38/17 , A61K9/00 , A61K31/728 , C07K14/47 , A61B5/00
摘要： An injectable aqueous formulation as well as a dosage form is disclosed for use in intra-articular injection of a specific peptide of SEQ ID NO: 1, whereby the joint pain at the injection site is relieved in the absence of detectable changes in joint cartilage formation, with pain particularly relieved under certain stress motions such as walking down stairs.
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公开(公告)号：US10849957B2
公开(公告)日：2020-12-01
申请号：US16006475
申请日：2018-06-12
申请人： ORTHOTROPHIX, INC.
发明人： Yoshinari Kumagai , Dawn McGuire , Meghan Miller , David Rosen
IPC分类号： A61K38/16 , A61K38/00 , A61K47/36 , A61K9/00 , A61P19/02 , C07K14/47 , A61K38/17 , A61K9/19 , A61K31/728 , A61B5/00
摘要： Making an initial evaluation of patient's joint pain when undergoing motions associated stress to the joint such as going up and down stairs, and injecting the patient with a peptide of SEQ ID No. 1, and thereafter evaluating the patient's joint pain when undergoing the same motion is disclosed.
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公开(公告)号：US20240299491A1
公开(公告)日：2024-09-12
申请号：US18601724
申请日：2024-03-11
申请人： ORTHOTROPHIX, Inc.
发明人： Yoshinari Kumagai , Dawn McGuire , Meghan Miller , David Rosen
CPC分类号： A61K38/1709 , A61B5/103 , A61B5/4504 , A61B5/4514 , A61B5/4528 , A61K9/0019
摘要： Knee pain caused by osteoarthritis is relieved by modifying the shape change of bone(s) underlying articular cartilage, by a method comprising evaluating the bone shape of the patient's joint, injecting the patient with a peptide of SEQ ID No. 1 or applying other therapeutic interventions that can reduce the shape change of the bone(s) underlying articular cartilage, and thereafter evaluating the bone shape of the patient's joint.
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公开(公告)号：US20220105154A1
公开(公告)日：2022-04-07
申请号：US17477918
申请日：2021-09-17
申请人： ORTHOTROPHIX, INC.
发明人： Yoshinari Kumagai , Dawn McGuire , Meghan Miller , David Rosen
摘要： Compounds, pharmaceutical compositions, and a method of treating hard tissue diseases and disorders are disclosed. The compounds may be a peptide and is structured to bind integrin αvβ3 expressed by osteocytes and by selective binding to the cell surface integrin on hard tissue forming cells regulate three-dimensional bone shape, cartilage formation and repair.
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公开(公告)号：US20190388503A1
公开(公告)日：2019-12-26
申请号：US16006638
申请日：2018-06-12
申请人： ORTHOTROPHIX, INC.
发明人： Yoshinari Kumagai , Dawn McGuire , Meghan Miller , David Rosen
摘要： An injectable aqueous formulation as well as a dosage form is disclosed for use in intra-articular injection of a specific peptide of SEQ ID NO: 1, whereby the joint pain at the injection site is relieved in the absence of detectable changes in joint cartilage formation, with pain particularly relieved under certain stress motions such as walking down stairs.
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公开(公告)号：US11963996B2
公开(公告)日：2024-04-23
申请号：US16586579
申请日：2019-09-27
申请人： ORTHOTROPHIX, Inc.
发明人： Yoshinari Kumagai , Dawn McGuire , Meghan Miller , David Rosen
CPC分类号： A61K38/1709 , A61B5/103 , A61B5/4504 , A61B5/4514 , A61B5/4528 , A61K9/0019
摘要： Knee pain caused by osteoarthritis is relieved by modifying the shape change of bone(s) underlying articular cartilage, by a method comprising evaluating the bone shape of the patient's joint, injecting the patient with a peptide of SEQ ID No. 1 or applying other therapeutic interventions that can reduce the shape change of the bone(s) underlying articular cartilage, and thereafter evaluating the bone shape of the patient's joint.
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公开(公告)号：US11413327B2
公开(公告)日：2022-08-16
申请号：US17085023
申请日：2020-10-30
申请人： ORTHOTROPHIX, INC.
发明人： Yoshinari Kumagai , Dawn McGuire , Meghan Miller , David Rosen
IPC分类号： A61K38/16 , A61K38/17 , A61K9/19 , A61K38/00 , A61K9/00 , A61K47/36 , A61P19/02 , C07K14/47 , A61K31/728 , A61B5/00
摘要： A method of alleviating joint pain in a patient comprising evaluating the patient's joint pain when undergoing motions associated stress to the joint, and injecting the patient with a peptide of SEQ ID No. 1, and thereafter evaluating the patient's joint pain when undergoing the same motion.
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