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公开(公告)号：US20160250276A1
公开(公告)日：2016-09-01
申请号：US15074142
申请日：2016-03-18
Applicant: OSAKA CITY UNIVERSITY
Inventor： Shinji Hirotsune
CPC classification number: A61K38/05 , A61K9/0019 , A61K9/0053 , A61K31/00
Abstract: An object of the present invention is to provide a medicament and method for treating lissencephaly patients. The present invention provides a lissencephaly therapeutic or preventive agent comprising a compound represented by the general formula (I): wherein R1 is lower alkyl substituted with lower alkoxy, lower alkyl substituted with a heterocyclic group, a heterocyclic group, or a group represented by the formula (IIa): wherein R4 is lower alkyl, R3 is lower alkylene, and m is an integer of 1 to 6; R2 is lower alkyl optionally substituted with phenyl; and R3 is lower alkyl optionally substituted with halogen, lower alkoxy, or phenyl; condensed polycyclic hydrocarbon; or hydrogen.
Abstract translation: 本发明的一个目的是提供一种用于治疗失精症患者的药物和方法。 本发明提供一种包含由通式（I）表示的化合物的解散性治疗剂或预防剂：其中R 1为被低级烷氧基取代的低级烷基，被杂环基取代的低级烷基，杂环基或由 式（IIa）：其中R 4为低级烷基，R 3为低级亚烷基，m为1至6的整数; R2是任选被苯基取代的低级烷基; 且R 3为任选被卤素，低级烷氧基或苯基取代的低级烷基; 稠合多环烃; 或氢气。
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公开(公告)号：US09539298B2
公开(公告)日：2017-01-10
申请号：US15074142
申请日：2016-03-18
Applicant: OSAKA CITY UNIVERSITY
Inventor： Shinji Hirotsune
CPC classification number: A61K38/05 , A61K9/0019 , A61K9/0053 , A61K31/00
Abstract: An object of the present invention is to provide a medicament and method for treating lissencephaly patients. The present invention provides a lissencephaly therapeutic or preventive agent comprising a compound represented by the general formula (I): wherein R1 is lower alkyl substituted with lower alkoxy, lower alkyl substituted with a heterocyclic group, a heterocyclic group, or a group represented by the formula (IIa): wherein R4 is lower alkyl, R3 is lower alkylene, and m is an integer of 1 to 6; R2 is lower alkyl optionally substituted with phenyl; and R3 is lower alkyl optionally substituted with halogen, lower alkoxy, or phenyl; condensed polycyclic hydrocarbon; or hydrogen.
Abstract translation: 本发明的一个目的是提供一种用于治疗失精症患者的药物和方法。 本发明提供一种包含由通式（I）表示的化合物的解散性治疗剂或预防剂：其中R 1为被低级烷氧基取代的低级烷基，被杂环基取代的低级烷基，杂环基或由 式（IIa）：其中R 4为低级烷基，R 3为低级亚烷基，m为1至6的整数; R2是任选被苯基取代的低级烷基; 且R 3为任选被卤素，低级烷氧基或苯基取代的低级烷基; 稠合多环烃; 或氢气。
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公开(公告)号：US11844776B2
公开(公告)日：2023-12-19
申请号：US16303629
申请日：2017-05-22
Applicant: OSAKA CITY UNIVERSITY , SENJU PHARMACEUTICAL CO., LTD.
Inventor： Shinji Hirotsune
IPC: A61K31/27 , A61P25/02 , A61K9/00 , A61K31/341 , A61K31/351 , A61K31/4402
CPC classification number: A61K31/27 , A61K9/0019 , A61K31/341 , A61K31/351 , A61K31/4402 , A61P25/02
Abstract: The present invention provides a means for treating and/or preventing peripheral nerve disorder by facilitating regeneration of peripheral nerves. Specifically, the present invention provides a composition for treating and/or preventing peripheral nerve disorder comprising a compound represented by the general formula (I):
wherein R1 is lower alkyl substituted with lower alkoxy, lower alkyl substituted with a heterocyclic group, a heterocyclic group, or a group represented by the formula (IIa):
R4O—R5m (IIa)
wherein R4 is lower alkyl, R5 is lower alkylene, and m is an integer of 1 to 6;
R2 is lower alkyl optionally substituted with phenyl; and
R3 is lower alkyl optionally substituted with halogen, lower alkoxy, or phenyl; condensed polycyclic hydrocarbon; or hydrogen.
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