公开(公告)号：US20180264015A1

公开(公告)日：2018-09-20

申请号：US15762644

申请日：2016-09-29

Applicant: OSAKA UNIVERSITY

Inventor： Nobuyuki TAKAKURA ,  Hisamichi NAITO ,  Kazuhiro TAKARA

IPC: A61K31/662 ,  A61K45/00 ,  A61K35/17 ,  A61P37/04 ,  A61K38/00 ,  A61P35/00 ,  A61K39/395

CPC classification number: A61K31/662 ,  A61K31/683 ,  A61K31/685 ,  A61K35/17 ,  A61K38/005 ,  A61K39/39558 ,  A61K45/00 ,  A61K45/05 ,  A61P35/00 ,  A61P37/04

Abstract: A lysophospholipid receptor-activating substance is able to normalize abnormal blood vessels in tumors without affecting normal blood vessels and to thus induce or promote infiltration of leukocytes into the whole or partial region of a tumor. Therefore, such a lysophospholipid receptor-activating substance is useful as a leukocyte infiltration promoter and an antitumor immunostimulant. Moreover, such a lysophospholipid receptor-activating substance can enhance cancer immunotherapy when used in combination with cancer immunotherapy, and is therefore useful as an agent for enhancing cancer immunotherapy.

公开(公告)号：US20220275343A1

公开(公告)日：2022-09-01

申请号：US17638026

申请日：2020-10-07

Applicant: OSAKA UNIVERSITY

Inventor： Nobuyuki TAKAKURA ,  Hisamichi NAITO ,  Taku WAKABAYASHI ,  Tomohiro IBA

IPC: C12N5/071

Abstract: The present invention provides a method for artificially producing a vascular endothelial stem cell from a non-vascular endothelial stem cell. The method for producing a vascular endothelial stem cell of the present invention comprises the step of bringing a vascular endothelial cell possessing no stem cell properties into contact with a factor secreted by an organ of a neonatal or juvenile mammal. The step may be a step of (1) transplanting the vascular endothelial cell possessing no stem cell properties into the organ of the neonatal or juvenile mammal, wherein the mammal is a non-human mammal, or (2) culturing the vascular endothelial cell possessing no stem cell properties in a culture system containing the factor secreted by the organ of the neonatal or juvenile mammal.