公开(公告)号：US20230285461A1

公开(公告)日：2023-09-14

申请号：US18185649

申请日：2023-03-17

申请人： Immatics Biotechnologies GmbH

发明人： Heiko SCHUSTER ,  Franziska HOFFGAARD ,  Jens FRITSCHE ,  Oliver SCHOOR ,  Toni WEINSCHENK ,  Daniel Johannes KOWALEWSKI ,  Chih-Chiang TSOU

IPC分类号： A61K35/17 ,  A61P35/00 ,  A61K39/39 ,  C07K16/28 ,  C07K7/06 ,  C07K14/54 ,  A61P35/02 ,  A61K39/00 ,  A61K45/06 ,  C12N5/0783 ,  A61K39/12 ,  C07K16/24 ,  A61K39/395 ,  A61K38/08 ,  C07K14/47

CPC分类号： A61K35/17 ,  A61P35/00 ,  A61K39/39 ,  C07K16/2818 ,  C07K7/06 ,  C07K14/5434 ,  A61P35/02 ,  A61K39/001102 ,  A61K45/06 ,  C12N5/0636 ,  A61K39/001114 ,  A61K39/001118 ,  A61K39/12 ,  C07K16/244 ,  A61K39/39558 ,  C07K16/2821 ,  A61K38/08 ,  C07K14/4748 ,  A61K2039/5156 ,  A61K45/05

摘要： The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.

公开(公告)号：US20230241114A1

公开(公告)日：2023-08-03

申请号：US18173174

申请日：2023-02-23

申请人： Immatics Biotechnologies GmbH

发明人： Heiko SCHUSTER ,  Franziska HOFFGAARD ,  Jens FRITSCHE ,  Oliver SCHOOR ,  Toni WEINSCHENK ,  Daniel Johannes KOWALEWSKI ,  Chih-Chiang TSOU

IPC分类号： A61K35/17 ,  A61P35/00 ,  A61K39/39 ,  C07K16/28 ,  C07K7/06 ,  C07K14/54 ,  A61P35/02 ,  A61K39/00 ,  A61K45/06 ,  C12N5/0783 ,  A61K39/12 ,  C07K16/24 ,  A61K39/395 ,  A61K38/08 ,  C07K14/47

CPC分类号： A61K35/17 ,  A61P35/00 ,  A61K39/39 ,  C07K16/2818 ,  C07K7/06 ,  C07K14/5434 ,  A61P35/02 ,  A61K39/001102 ,  A61K45/06 ,  C12N5/0636 ,  A61K39/001114 ,  A61K39/001118 ,  A61K39/12 ,  C07K16/244 ,  A61K39/39558 ,  C07K16/2821 ,  A61K38/08 ,  C07K14/4748 ,  A61K2039/5156 ,  A61K45/05

摘要： The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.

公开(公告)号：US11697804B2

公开(公告)日：2023-07-11

申请号：US16589647

申请日：2019-10-01

申请人： The Johns Hopkins University

发明人： Jordan J. Green ,  Martin G. Pomper ,  Camila Gadens Zamboni ,  Hannah Vaughan ,  Il Minn

IPC分类号： C12N9/12 ,  C12N15/52 ,  A61K48/00 ,  C12N15/85 ,  A61K35/00 ,  C08G73/02 ,  A61K51/04 ,  B82Y5/00 ,  A61K45/00 ,  A61K31/522

CPC分类号： C12N9/1211 ,  A61K35/00 ,  A61K48/0041 ,  C08G73/02 ,  C12N15/52 ,  C12N15/85 ,  A61K31/522 ,  A61K45/05 ,  A61K51/0459 ,  B82Y5/00 ,  C12N2820/007 ,  C12N2830/008 ,  C12N2830/15 ,  C12N2840/007 ,  C12N2840/60 ,  C12Y207/01021

摘要： A DNA plasmid useful for diagnostic and therapeutic gene therapy is disclosed. Improvements to gene therapy methods known in the art are provided to ensure cancer-targeting, high efficacy, and long durability of expression. The DNA plasmid is combined with compositions of polymeric nanoparticles for non-viral gene therapy to treat cancer, including hepatocellular carcinoma and prostate cancer.

公开(公告)号：US20180326027A1

公开(公告)日：2018-11-15

申请号：US15774736

申请日：2016-11-09

申请人： THE UNIVERSITY OF BRITISH COLUMBIA

发明人： Neil R. CASHMAN ,  Steven S. PLOTKIN

IPC分类号： A61K39/00 ,  A61K45/00 ,  A61K47/64 ,  A61P25/28 ,  A61P37/06 ,  C07K14/47 ,  C07K16/18 ,  C07K5/103 ,  C07K5/107 ,  C07K5/113 ,  C07K7/06 ,  C07K7/64

CPC分类号： A61K39/0008 ,  A61K39/0007 ,  A61K45/05 ,  A61K47/643 ,  A61K47/646 ,  A61K2039/505 ,  A61K2039/6081 ,  A61K2300/00 ,  A61P25/28 ,  A61P37/06 ,  C07K5/1008 ,  C07K5/1016 ,  C07K5/1021 ,  C07K7/06 ,  C07K7/64 ,  C07K14/47 ,  C07K14/4711 ,  C07K16/18 ,  C07K2317/76 ,  G01N2333/4709

摘要： The disclosure pertains to epitopes identified in A-beta including conformational epitopes, antibodies thereto and methods of making and using immunogens and antibodies specific thereto.

公开(公告)号：US20180125936A1

公开(公告)日：2018-05-10

申请号：US15564183

申请日：2016-03-23

申请人： PARANTA BIOSCIENCES LIMITED

发明人： David N. WATKINS ,  Kieren D. MARINI ,  David Morritz DE KRETSER

IPC分类号： A61K38/18 ,  A61K31/255 ,  A61K31/4439 ,  A61K31/555 ,  A61K33/24 ,  A61K38/17 ,  A61K38/22 ,  A61K39/00 ,  A61K45/00 ,  A61P35/00

CPC分类号： A61K38/18 ,  A61K31/255 ,  A61K31/4439 ,  A61K31/555 ,  A61K33/24 ,  A61K38/1709 ,  A61K38/177 ,  A61K38/22 ,  A61K39/00 ,  A61K39/0011 ,  A61K45/05 ,  A61K45/06 ,  A61K2300/00 ,  A61P35/00 ,  C12N2310/127 ,  C12N2310/16

摘要： The present invention relates generally to a method of treating a neoplastic condition. More particularly, the present invention is directed to a method of selectively sensitising neoplastic cells prior to chemotherapy. The method of the present invention is predicated on administering chemotherapy treatment subsequently to neoplastic cell sensitisation via the exposure of these cells to an activin type 1 B receptor (ACVR1B) antagonist. The present findings have now enabled the development of a new neoplastic treatment regime exhibiting both higher efficacy and reduced side effects for patients and, still further, a means of effectively treating chemoresistant neoplasms.

公开(公告)号：US20170095510A1

公开(公告)日：2017-04-06

申请号：US15315709

申请日：2015-05-29

申请人： Cellics Therapeutics, Inc.

发明人： Tien-Li LEE

IPC分类号： A61K35/18 ,  A61K45/00 ,  A61K9/50

CPC分类号： A61K35/18 ,  A61K9/5031 ,  A61K9/5068 ,  A61K45/05

摘要： The present invention relates to methods, combinations and pharmaceutical compositions for treating or preventing a hemolytic disease or condition in a mammal, wherein: said hemolytic disease or condition is caused by an attack of said mammal's red blood cells by said mammal's own body, or said mammal is a pregnant mammal and said hemolytic disease or condition of a fetus of said pregnant mammal is caused by an attack of said fetus' red blood cells by an antibody of said pregnant mammal, or said mammal is a baby and said hemolytic disease or condition of said baby is caused by an attack of said baby's red blood cells by an antibody of said baby's mother. The exemplary hemolytic diseases or conditions include hemophagocytic lymphohistiocytosis, an autoimmune disease or condition, or a hereditary hemolytic disease or disorder.

公开(公告)号：US20110311624A1

公开(公告)日：2011-12-22

申请号：US12761588

申请日：2010-04-16

申请人： David J. LOURY ,  Joseph J. BUGGY ,  Tarak D. MODY ,  Erik J. VERNER ,  Norbert PURRO ,  Sriram BALASUBRAMANIAN

发明人： David J. LOURY ,  Joseph J. BUGGY ,  Tarak D. MODY ,  Erik J. VERNER ,  Norbert PURRO ,  Sriram BALASUBRAMANIAN

IPC分类号： A61K31/69 ,  A61K31/47 ,  A61K31/166 ,  A61P35/00 ,  A61K31/40 ,  A61K31/497 ,  A61K31/35 ,  A61K9/28 ,  A61K31/343 ,  A61K31/381

CPC分类号： A61N5/10 ,  A61K9/205 ,  A61K9/2054 ,  A61K9/2826 ,  A61K9/2846 ,  A61K9/2866 ,  A61K9/4808 ,  A61K9/4858 ,  A61K9/4866 ,  A61K9/501 ,  A61K9/5026 ,  A61K31/166 ,  A61K31/343 ,  A61K31/35 ,  A61K31/381 ,  A61K31/40 ,  A61K31/4184 ,  A61K31/47 ,  A61K31/497 ,  A61K31/573 ,  A61K31/69 ,  A61K31/704 ,  A61K38/05 ,  A61K45/05 ,  A61K45/06 ,  A61K47/02 ,  A61K47/12 ,  C07D307/85

摘要： Dosing regimens, methods of treatment, controlled release formulations, and combination therapies that include an HDAC inhibitor, or a pharmaceutically acceptable salt thereof, are described.

摘要翻译： 描述了给药方案，治疗方法，控释制剂和包括HDAC抑制剂或其药学上可接受的盐的组合疗法。

公开(公告)号：US07189834B2

公开(公告)日：2007-03-13

申请号：US10800926

申请日：2004-03-15

申请人： William E. Marshall

发明人： William E. Marshall

IPC分类号： C07H19/00

CPC分类号： A61K35/74 ,  A23K10/18 ,  A23K50/10 ,  A61K31/7088 ,  A61K35/747 ,  A61K39/39 ,  A61K45/05 ,  A61K2039/55561 ,  C12N1/20

摘要： This invention provides novel methods and compositions for modulating and stimulating the immune system of animals to withstand microbial infections and the lethality of endotoxic shock by feeding or injecting bacteria-free oligoribonucleotides (ORNs) released by either harmless or pathogenic bacteria. The invention also describes the molecular mode of action of the health benefits derived from consuming fermented dairy products and probiotic bacteria.

摘要翻译： 本发明提供用于调节和刺激动物的免疫系统以经受微生物感染和内毒素性休克的致死性的新型方法和组合物，其通过饲养或注射由无害细菌或致病菌释放的无细菌的寡核糖核苷酸（ORN）。 本发明还描述了从消费发酵乳制品和益生菌获得的健康益处的分子作用方式。

公开(公告)号：US5231085A

公开(公告)日：1993-07-27

申请号：US837712

申请日：1992-02-19

申请人： J. Wesley Alexander ,  Vigen K. Babayan ,  George L. Blackburn ,  Frank B. Cerra ,  John Daly ,  Mitchell T. Gersovitz ,  John E. Kinsella ,  Jerome J. LiCari ,  Frederick Rudolph ,  Charles T. Van Buren

发明人： J. Wesley Alexander ,  Vigen K. Babayan ,  George L. Blackburn ,  Frank B. Cerra ,  John Daly ,  Mitchell T. Gersovitz ,  John E. Kinsella ,  Jerome J. LiCari ,  Frederick Rudolph ,  Charles T. Van Buren

IPC分类号： A23L1/29 ,  A23L1/30 ,  A61K31/20 ,  A61K45/00

CPC分类号： A61K31/20 ,  A23L33/12 ,  A23L33/40 ,  A61K31/70 ,  A61K45/05 ,  Y10S514/885

摘要： The invention provides immunostimulatory compositions comprising an aggregate immunostimulatory amount ofa) a compound associated with the synthesis of polyamines,b) a nucleobase source,c) omega-3 polyunsaturated fatty acids, andd) omega-6 polyunsaturated fatty acidsthe use of such compositions and their manufacture.

摘要翻译： 本发明提供免疫刺激组合物，其包含总体免疫刺激量的a）与多胺合成相关的化合物，b）核碱源，c）ω-3多不饱和脂肪酸和d）ω-6多不饱和脂肪酸，其使用 组合物及其制造。

公开(公告)号：US4987237A

公开(公告)日：1991-01-22

申请号：US112742

申请日：1987-10-22

申请人： Kent R. Myers ,  Edgar F. Ribi, deceased

发明人： Kent R. Myers ,  Edgar F. Ribi, deceased

IPC分类号： A61K39/39 ,  A61K35/74 ,  A61K38/00 ,  A61K39/385 ,  A61K45/00 ,  C07H13/04 ,  C07H13/06 ,  C07K9/00 ,  C07K17/06 ,  G01N33/53

CPC分类号： C07H13/06 ,  A61K45/05 ,  C07K17/06 ,  C07K9/001

摘要： Novel derivatives of monophosphoryl lipid A and a process for their preparation are provided. The derivatives contain one or more free groups, such as an amine, on a side chain attached to the primary hydroxyl groups of the monophosphoryl lipid A nucleus through an ester group. The derivatives provide a convenient method for coupling the lipid A through coupling agents to various biologically active materials, substrates, and the like, wherein the immunostimulant properties of lipid A are desired.

摘要翻译： 提供单磷酰脂质A的新型衍生物及其制备方法。 衍生物在通过酯基与单磷酰脂质A核的伯羟基连接的侧链上含有一个或多个游离基团，例如胺。 衍生物提供了通过偶联剂将脂质A偶联到各种生物活性物质，底物等上的便利方法，其中期望脂质A的免疫刺激性质。