公开(公告)号：US11731917B2

公开(公告)日：2023-08-22

申请号：US16636236

申请日：2018-08-03

Applicant: OSAKA UNIVERSITY

Inventor： Yoshifumi Shirakami ,  Hayato Ikeda ,  Yasukazu Kanai ,  Eku Shimosegawa ,  Jun Hatazawa ,  Tadashi Watabe ,  Kazuko Kaneda

IPC: C07B59/00 ,  C07F13/00 ,  C07F5/02

CPC classification number: C07B59/001 ,  C07B59/004 ,  C07F5/025 ,  C07F13/00 ,  C07F13/005 ,  C07B2200/05

Abstract: The invention relates to a method of producing the radiolabeled aryl compound (I) Ar—X, or a salt thereof, wherein X is 211At, 210At, 123I, 124I, 125I, or 131I. The method involves reacting the aryl boronic acid compound (II) Ar—Y, or a salt thereof, wherein Y is a borono group (—B(OH)2) or an ester group thereof, with a radionuclide selected from 211At, 210At, 123I, 124I, 125I and 131I, in the presence of an oxidizing agent selected from an alkali metal iodide, an alkali metal bromide, N-bromosuccinimide, N-chlorosuccinimide and hydrogen peroxide, in water.

公开(公告)号：US11684683B2

公开(公告)日：2023-06-27

申请号：US16958147

申请日：2018-12-28

Applicant: OSAKA UNIVERSITY

Inventor： Yoshifumi Shirakami ,  Tadashi Watabe ,  Kazuko Kaneda ,  Eku Shimosegawa ,  Atsushi Shinohara ,  Jun Hatazawa

IPC: A61K51/12 ,  A61K47/22

CPC classification number: A61K51/121 ,  A61K47/22

Abstract: The invention provides a method for producing a solution containing 211At− (astatide ion) at a high radiochemical purity by using 211At obtained by a nuclear reaction as a starting material, including a step of adding a reducing agent to a solution containing an impurity derived from 211At. The invention also provides a solution containing 211At− (astatide ion) at a radiochemical purity of not less than 30%.