公开(公告)号：US12202218B2

公开(公告)日：2025-01-21

申请号：US17254120

申请日：2019-06-20

Applicant: OSAKA UNIVERSITY

Inventor： Kohji Nishida ,  Koichi Baba ,  Shizuka Koh ,  Kei Ohkubo ,  Haruyasu Asahara ,  Tsuyoshi Inoue ,  Hiroshi Uyama ,  Taka-Aki Asoh

IPC: B29D11/00 ,  A61F2/16 ,  C08L101/12

Abstract: The present invention provides a new method for producing a lens to be fitted to an eye in a simple manner at a low cost. In order to achieve the aforementioned object, the present invention provides a method for producing a lens to be fitted to an eye, including the step of: hydrophilizing a surface of a polymer lens by reacting with a compound radical, wherein the compound radical is a radical containing one element selected from the group consisting of Group 15 elements and Group 16 elements, and a Group 17 element.

公开(公告)号：US20150087624A1

公开(公告)日：2015-03-26

申请号：US14395952

申请日：2013-04-23

Applicant: OSAKA UNIVERSITY

Inventor： Koichi Baba ,  Kohji Nishida ,  Noriyasu Hashida

IPC: A61K9/10 ,  A61K31/57 ,  A61K9/00 ,  A61K31/27

CPC classification number: A61K9/10 ,  A61K9/0014 ,  A61K9/0048 ,  A61K9/19 ,  A61K31/27 ,  A61K31/57 ,  A61K47/44 ,  A61K51/082 ,  B82Y5/00 ,  B82Y40/00

Abstract: A nanoparticle aqueous dispersion in which nanoparticles are dispersed in water is produced through a method including a step of freeze-drying a frozen sample of a liquid mixture of a first solution and a second solution and a step of dispersing the freeze-dried sample in water. In this method, the liquid mixture contains an active ingredient and an ointment base, the first solution includes contains an organic solvent as its solvent, and the second solution contains water as its solvent. The method, which is arranged as such, can provide an aqueous composition containing nanoparticles dispersed therein and usable stably as an aqueous dispersion preparation.

Abstract translation: 通过包括冷冻干燥第一溶液和第二溶液的液体混合物的冷冻样品的步骤的方法制备纳米颗粒分散在水中的纳米颗粒水分散体，以及将冷冻干燥样品分散在水中的步骤 。 在该方法中，液体混合物含有活性成分和软膏基质，第一溶液包含有机溶剂作为溶剂，第二溶液含有水作为溶​​剂。 这样布置的方法可以提供含有分散在其中的纳米颗粒的水性组合物，并可稳定地用作水分散体制剂。