公开(公告)号：US20150087624A1

公开(公告)日：2015-03-26

申请号：US14395952

申请日：2013-04-23

Applicant: OSAKA UNIVERSITY

Inventor： Koichi Baba ,  Kohji Nishida ,  Noriyasu Hashida

IPC: A61K9/10 ,  A61K31/57 ,  A61K9/00 ,  A61K31/27

CPC classification number: A61K9/10 ,  A61K9/0014 ,  A61K9/0048 ,  A61K9/19 ,  A61K31/27 ,  A61K31/57 ,  A61K47/44 ,  A61K51/082 ,  B82Y5/00 ,  B82Y40/00

Abstract: A nanoparticle aqueous dispersion in which nanoparticles are dispersed in water is produced through a method including a step of freeze-drying a frozen sample of a liquid mixture of a first solution and a second solution and a step of dispersing the freeze-dried sample in water. In this method, the liquid mixture contains an active ingredient and an ointment base, the first solution includes contains an organic solvent as its solvent, and the second solution contains water as its solvent. The method, which is arranged as such, can provide an aqueous composition containing nanoparticles dispersed therein and usable stably as an aqueous dispersion preparation.

Abstract translation: 通过包括冷冻干燥第一溶液和第二溶液的液体混合物的冷冻样品的步骤的方法制备纳米颗粒分散在水中的纳米颗粒水分散体，以及将冷冻干燥样品分散在水中的步骤 。 在该方法中，液体混合物含有活性成分和软膏基质，第一溶液包含有机溶剂作为溶剂，第二溶液含有水作为溶​​剂。 这样布置的方法可以提供含有分散在其中的纳米颗粒的水性组合物，并可稳定地用作水分散体制剂。

公开(公告)号：US12013365B2

公开(公告)日：2024-06-18

申请号：US17258662

申请日：2019-07-18

Applicant: OSAKA UNIVERSITY

Inventor： Kohji Nishida ,  Noriyasu Hashida ,  Masateru Taniguchi ,  Makusu Tsutsui

IPC: G01N27/327 ,  G01N27/447 ,  G01N33/487 ,  G01N33/569

CPC classification number: G01N27/3278 ,  G01N27/447 ,  G01N33/48721 ,  G01N33/56983

Abstract: Provided are a virus measuring method, a virus measuring device, a virus determining program, a stress determining method, and a stress determining device. A virus measuring method includes a contact step of bringing a liquid specimen containing a body fluid of a subject and an electrolytic solution into contact with each other via a through-hole portion formed in a separating wall, a current measuring step of applying a voltage to the liquid specimen and the electrolytic solution with respect to the through-hole portion and obtaining a waveform of an ionic current flowing through the through-hole portion, and a virus determining step of determining the kind of a virus contained in the body fluid on the basis of the waveform. In the virus determining step, the kind of the virus is determined by comparing the waveform with waveform information that corresponds to a known virus and is obtained beforehand.

公开(公告)号：US20190119747A1

公开(公告)日：2019-04-25

申请号：US16089317

申请日：2017-03-28

Applicant: Osaka University

Inventor： Kohji Nishida ,  Atsushi Kumanogoh ,  Noriyasu Hashida

IPC: C12Q1/6876

Abstract: The principal purpose of the present invention is to provide a novel stress biomarker that makes it possible to conveniently and accurately assess a state of stress. In addition, the present invention provides a diagnosis kit containing a reagent capable of detecting said biomarker, and a diagnosis method that uses said biomarker. It is possible to use mitochondrial DNA included in a biological fluid as the stress biomarker.

公开(公告)号：US12035973B2

公开(公告)日：2024-07-16

申请号：US16964029

申请日：2019-01-25

Applicant: OSAKA UNIVERSITY

Inventor： Kohji Nishida ,  Kazuichi Maruyama ,  Noriyasu Hashida ,  Reiko Kobayashi

IPC: A61B3/14 ,  A61B3/10 ,  A61B5/16

CPC classification number: A61B3/14 ,  A61B3/102 ,  A61B5/165

Abstract: A method for detecting a stressed state, including a step of detecting a stressed state of a subject based on a tomographic image of a choroid of the subject, and a stress detection apparatus including: an image acquisition unit that acquires a tomographic image of a choroid of a subject; a calculation unit that calculates a choroidal thickness or a volume of the choroid based on the tomographic image; and a detection unit that detects a stressed state of the subject based on the choroidal thickness or the volume of the choroid.

公开(公告)号：US20200270686A1

公开(公告)日：2020-08-27

申请号：US16089114

申请日：2017-03-28

Applicant: Osaka University

Inventor： Kohji Nishida ,  Atsushi Kumanogoh ,  Noriyasu Hashida

IPC: C12Q1/6883

Abstract: The principal purpose of the present invention is to provide a biomarker that makes it possible to conveniently and accurately assess corneal or conjunctival disease, and can use lacrimal fluid as the sample thereof. In addition, a main object of the present invention is to provide a biomarker that makes it possible to conveniently and accurately evaluate central serous chorioretinopathy. The present invention also provides a diagnostic kit containing a reagent capable of detecting the biomarker, and a diagnosis method that uses the biomarker. It is possible to use mitochondrial DNA included in lacrimal fluid as the biomarker for corneal or conjunctival disease.