公开(公告)号：US20250163370A1

公开(公告)日：2025-05-22

申请号：US18836137

申请日：2023-02-06

Applicant: OSAKA UNIVERSITY

Inventor： Masahiro KINOOKA ,  Meehae KIM ,  Yukako GUJINAGA

IPC: C12N5/079

Abstract: A method for producing a retinal pigment epithelial (RPE) cell is disclosed. The method includes promoting a differentiation induction from a pluripotent stem cell into an RPE cell by culturing the pluripotent stem cell in a medium containing an E-cadherin inhibitor. The medium may further contain a differentiation inducer. The pluripotent stem cell may be an embryonic stem(ES) cell or an induced pluripotent stem (iPS) cell.

公开(公告)号：US20250163369A1

公开(公告)日：2025-05-22

申请号：US18836633

申请日：2023-02-06

Applicant: OSAKA UNIVERSITY

Inventor： Masahiro KINOOKA ,  Meehae KIM ,  Yukako FUJINAGA

IPC: C12N5/071 ,  C12N5/00

Abstract: An agent for directional control of differentiation induction of a pluripotent stem cell, which contains an E-cadherin inhibitor, and its uses are disclosed. A method for controlling the directionality of differentiation induction of a pluripotent stem cell is also disclosed. The method includes a step of culturing a pluripotent stem cell in a medium comprising an E-cadherin inhibitor.