公开(公告)号：US12071624B2

公开(公告)日：2024-08-27

申请号：US17250806

申请日：2019-09-04

Applicant: OSAKA UNIVERSITY ,  NATIONAL INSTITUTES OF BIOMEDICAL INNOVATION, HEALTH AND NUTRITION ,  NATIONAL UNIVERSITY CORPORATION KOBE UNIVERSITY

Inventor： Akira Kikuchi ,  Shinji Matsumoto ,  Satoshi Obika ,  Yuya Kasahara ,  Takumi Fukumoto

IPC: C07H21/04 ,  A61P35/04 ,  C12N15/113

CPC classification number: C12N15/1137 ,  A61P35/04 ,  C12N2310/11 ,  C12N2310/315

Abstract: The purpose of the present invention is to provide an antisense oligonucleotide that targets an ARL4C molecule and exerts an antitumor effect in vivo, and a nucleic acid drug using the antisense oligonucleotide. An antisense oligonucleotide that has a base sequence consisting of at least 10 consecutive bases contained in the base sequence represented by SEQ ID NO: 1. This antisense oligonucleotide targets an ARL4C molecule and thus can inhibit the expression of ARL4C in a tumor cell in vitro and suppress the migration and proliferation thereof. When systemically administered, moreover, the antisense oligonucleotide can exert an excellent antitumor effect in vivo too.

公开(公告)号：US20220249538A1

公开(公告)日：2022-08-11

申请号：US17595703

申请日：2020-05-22

Applicant: OSAKA UNIVERSITY

Inventor： Akira Kikuchi ,  Shinji Matsumoto ,  Taku Yamamichi

IPC: A61K31/7105 ,  G01N33/574 ,  C12Q1/6886 ,  A61P35/00 ,  A61K31/713

Abstract: The purpose of the present invention is to provide a novel tumor treatment agent. In GREB1-positive tumors that do not exhibit sex hormone sensitivity, GREB1 is a downstream target gene of the Wnt/β-catenin signal. Through the use as an active ingredient of a substance that can inhibit GREB1 expression, the growth of GREB1-positive tumor cells that do not exhibit sex hormone sensitivity can be effectively inhibited and such a tumor can be treated.