公开(公告)号：US20220249538A1

公开(公告)日：2022-08-11

申请号：US17595703

申请日：2020-05-22

Applicant: OSAKA UNIVERSITY

Inventor： Akira Kikuchi ,  Shinji Matsumoto ,  Taku Yamamichi

IPC: A61K31/7105 ,  G01N33/574 ,  C12Q1/6886 ,  A61P35/00 ,  A61K31/713

Abstract: The purpose of the present invention is to provide a novel tumor treatment agent. In GREB1-positive tumors that do not exhibit sex hormone sensitivity, GREB1 is a downstream target gene of the Wnt/β-catenin signal. Through the use as an active ingredient of a substance that can inhibit GREB1 expression, the growth of GREB1-positive tumor cells that do not exhibit sex hormone sensitivity can be effectively inhibited and such a tumor can be treated.