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公开(公告)号：US20200206300A1
公开(公告)日：2020-07-02
申请号：US16619879
申请日：2018-06-12
Applicant: OSAKA UNIVERSITY
Inventor： Susumu TANAKA , Mikihiko KOGO , Hirofumi YAMAMOTO , Naomasa KAWAGUCHI , Yoshinosuke HAMADA
Abstract: The present invention provides an agent for promoting skeletal muscle injury repair which agent comprises at least one peptide selected from the following (1) to (4): (1) a peptide consisting of the amino acid sequence of SEQ ID NO: 1, (2) a peptide consisting of the amino acid sequence of SEQ ID NO: 2, (3) a peptide consisting of the amino acid sequence of SEQ ID NO: 3, and (4) a peptide which is a human osteopontin fragment and has the amino acid sequence of SEQ ID NO: 1, 2, or 3 at the C-terminus, or a salt thereof as an active ingredient.
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2.发明公开公开(公告)号：US20230381275A1
公开(公告)日：2023-11-30
申请号：US18033452
申请日：2021-10-22
Applicant: OSAKA UNIVERSITY
Inventor： Susumu TANAKA , Yoshinosuke HAMADA , Mikihiko KOGO , Hirofumi YAMAMOTO , Naomasa KAWAGUCHI
Abstract: [Problem] The present invention addresses the problem of providing a muscle function-improving agent for suppressing or improving the decline of muscular functions due to aging. [Solution] Provided is a muscle function-improving agent for suppressing or improving the functional decline of skeletal muscle due to aging, the muscle function-improving agent containing, as an active ingredient, at least one peptide selected from among the following (1)-(3), or a salt thereof: (1) a peptide consisting of the amino acid sequence represented by SEC) ID NO: 1; (2) a peptide which is the fragment of human osteopontin, and in which the C-terminal amino acid sequence is the amino acid sequence represented by SEQ ID NO: 1; and (3) a peptide which consists of an amino acid sequence obtained by substituting, adding, or deleting one or more amino acids in the amino acid sequence of the peptide in (1) or (2), and has the action of suppressing or ameliorating the functional decline of skeletal muscle due to aging.
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