公开(公告)号：US11020464B2

公开(公告)日：2021-06-01

申请号：US16486768

申请日：2018-02-20

Applicant: OSAKA UNIVERSITY ,  FUNPEP CO., LTD.

Inventor： Munehisa Shimamura ,  Tomohiro Kawano ,  Hironori Nakagami ,  Ryuichi Morishita ,  Hideki Mochizuki ,  Akiko Tenma ,  Takako Ehara

IPC: A61K39/00 ,  A61P7/02 ,  A61P9/10 ,  A61K39/39 ,  A61K47/42 ,  C07K14/435

Abstract: Provided is an immunogenic composition comprising an antigenic peptide capable of inducing production of a neutralizing antibody against S100A9 and a carrier protein. The immunogenic composition can be used as a highly safe antithrombotic vaccine having antithrombotic effect without a long-term bleeding risk and is useful for the prevention of a disease associated with thrombus formation in which platelet aggregation is involved, particularly for the prevention of recurrent ischemic stroke.