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公开(公告)号：US20200023045A1
公开(公告)日：2020-01-23
申请号：US16486768
申请日：2018-02-20
Applicant: OSAKA UNIVERSITY , FUNPEP CO., LTD.
Inventor： Munehisa SHIMAMURA , Tomohiro KAWANO , Hironori NAKAGAMI , Ryuichi MORISHITA , Hideki MOCHIZUKI , Akiko TENMA , Takako EHARA
Abstract: Provided is an immunogenic composition comprising an antigenic peptide capable of inducing production of a neutralizing antibody against S100A9 and a carrier protein. The immunogenic composition can be used as a highly safe antithrombotic vaccine having antithrombotic effect without a long-term bleeding risk and is useful for the prevention of a disease associated with thrombus formation in which platelet aggregation is involved, particularly for the prevention of recurrent ischemic stroke.
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公开(公告)号：US20250057928A1
公开(公告)日：2025-02-20
申请号：US18717944
申请日：2022-12-07
Applicant: OSAKA UNIVERSITY , FunPep Co., Ltd.
Inventor： Hironori NAKAGAMI , Hiroki HAYASHI , Ryuichi MORISHITA , Makoto SAKAGUCHI , Sotaro KAWABATA
Abstract: The present invention provides a vaccine composition containing a complex of a T cell receptor antigen peptide and a B cell receptor antigen peptide and capable of inducing the production of an antibody against IL-23, wherein the B cell receptor antigen peptide is represented by the following formula (I): X1-X2-X3-X4-X5-X6-X7-X8 (I) wherein X1 is S, A, G, T, K, or R, X2 is P, A, G, S, T, K, or R, X3 is S, A, G, T, K, or R, X4 is Q, A, G, T, or N, X5 is P, A, G, S, T, Q, or N, X6 is W, A, Y, or E, X7 is Q, A, G, T, or N, and X8 is R, A, G, or K.
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Patent Agency Ranking
公开(公告)号：US10980876B2
公开(公告)日：2021-04-20
申请号：US16087799
申请日：2017-03-24
Applicant: OSAKA UNIVERSITY , FUNPEP CO., LTD.
Inventor： Hironori Nakagami , Ryuichi Morishita , Akiko Tenma
IPC: A61K39/395 , A61K39/39 , A61K39/00 , A61P37/04
Abstract: The present invention provides a vaccine containing a complex of a peptide consisting of the amino acid sequence of SEQ ID NO: 1 and an epitope of a disease-causing biological protein such as DPP4, IL-17A, IgE, S100A9 or PCSK9, which vaccine uses a less antigenic carrier protein and is capable of inducing antibody production to serve as an effective vaccine.
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公开(公告)号：US20190105388A1
公开(公告)日：2019-04-11
申请号：US16087799
申请日：2017-03-24
Applicant: OSAKA UNIVERSITY , FUNPEP CO., LTD.
Inventor： Hironori NAKAGAMI , Ryuichi MORISHITA , Akiko TENMA
IPC: A61K39/39 , A61P37/04 , A61K39/395 , A61K39/00
Abstract: The present invention provides a vaccine containing a complex of a peptide consisting of the amino acid sequence of SEQ ID NO: 1 and an epitope of a disease-causing biological protein such as DPP4, IL-17A, IgE, S100A9 or PCSK9, which vaccine uses a less antigenic carrier protein and is capable of inducing antibody production to serve as an effective vaccine.
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公开(公告)号：US12070498B2
公开(公告)日：2024-08-27
申请号：US17200552
申请日：2021-03-12
Applicant: OSAKA UNIVERSITY , FUNPEP CO., LTD.
Inventor： Hironori Nakagami , Ryuichi Morishita , Akiko Tenma
IPC: A61K39/395 , A61K39/00 , A61K39/39 , A61P37/04
CPC classification number: A61K39/39 , A61K39/00 , A61K39/00114 , A61K39/39533 , A61P37/04 , A61K2039/55527
Abstract: The present invention provides a vaccine containing a complex of a peptide consisting of the amino acid sequence of SEQ ID NO: 1 and an epitope of a disease-causing biological protein such as DPP4, IL-17A, IgE, S100A9 or PCSK9, which vaccine uses a less antigenic carrier protein and is capable of inducing antibody production to serve as an effective vaccine.
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公开(公告)号：US20210205446A1
公开(公告)日：2021-07-08
申请号：US17200552
申请日：2021-03-12
Applicant: OSAKA UNIVERSITY , FUNPEP CO., LTD.
Inventor： Hironori NAKAGAMI , Ryuichi MORISHITA , Akiko TENMA
IPC: A61K39/39 , A61K39/00 , A61P37/04 , A61K39/395
Abstract: The present invention provides a vaccine containing a complex of a peptide consisting of the amino acid sequence of SEQ ID NO: 1 and an epitope of a disease-causing biological protein such as DPP4, IL-17A, IgE, S100A9 or PCSK9, which vaccine uses a less antigenic carrier protein and is capable of inducing antibody production to serve as an effective vaccine.
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公开(公告)号：US11020464B2
公开(公告)日：2021-06-01
申请号：US16486768
申请日：2018-02-20
Applicant: OSAKA UNIVERSITY , FUNPEP CO., LTD.
Inventor： Munehisa Shimamura , Tomohiro Kawano , Hironori Nakagami , Ryuichi Morishita , Hideki Mochizuki , Akiko Tenma , Takako Ehara
Abstract: Provided is an immunogenic composition comprising an antigenic peptide capable of inducing production of a neutralizing antibody against S100A9 and a carrier protein. The immunogenic composition can be used as a highly safe antithrombotic vaccine having antithrombotic effect without a long-term bleeding risk and is useful for the prevention of a disease associated with thrombus formation in which platelet aggregation is involved, particularly for the prevention of recurrent ischemic stroke.
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