公开(公告)号：US20230110381A1

公开(公告)日：2023-04-13

申请号：US17908283

申请日：2021-03-04

Applicant: OSAKA UNIVERSITY ,  TOPPAN INC.

Inventor： Michiya MATSUSAKI ,  Naoko SASAKI ,  Shiro KITANO ,  Shinji IRIE

IPC: A61L27/50 ,  A61L27/36 ,  A61L27/24 ,  A61L27/38 ,  C12N5/00

Abstract: Disclosed is a method for controlling the Young’s modulus of a three-dimensional tissue containing cells and an extracellular matrix by adjusting the average diameter of an extracellular matrix in production of the three-dimensional tissue.

公开(公告)号：US20220341918A1

公开(公告)日：2022-10-27

申请号：US17642608

申请日：2020-08-27

Applicant: TOPPAN INC. ,  Osaka University

Inventor： Shiro KITANO ,  Shinji IRIE ,  Michiya MATSUSAKI ,  Naoko SASAKI ,  Atsuo AMANO ,  Hiroki TAKEUCHI

IPC: G01N33/50 ,  C12N5/071

Abstract: Provided is a cell structure including: a connective tissue structure; and an epithelial structure placed on the connective tissue structure, in which the connective tissue structure contains a fragmented extracellular matrix component and first cells including mesenchymal cells, at least a part of the fragmented extracellular matrix component is placed between the first cells, and the epithelial structure contains epithelial cells.