公开(公告)号：US20230167407A1

公开(公告)日：2023-06-01

申请号：US17997377

申请日：2021-04-28

Applicant: OSPEDALE SAN RAFFAELE S.R.L.

Inventor： Barbara CAMISA ,  Monica CASUCCI ,  Silvia ARCANGELI ,  Claudia MEZZANOTTE ,  Laura FALCONE ,  Maria Chiara BONINI

IPC: C12N5/0783 ,  C12N15/86 ,  A61P35/00

CPC classification number: C12N5/0636 ,  C12N15/86 ,  A61P35/00 ,  C12N2501/2307 ,  C12N2501/2315 ,  C12N2740/15043

Abstract: The present invention refers to a method to produce a T cell with advantageous properties. The invention also refers to a T cell or an engineered T cell produced by the method and its use in therapy.

公开(公告)号：US20150306142A1

公开(公告)日：2015-10-29

申请号：US14660484

申请日：2015-03-17

Applicant: OSPEDALE SAN RAFFAELE S.R.L.

Inventor： Maria Chiara BONINI ,  Attilio BONDANZA

IPC: A61K35/17 ,  C12N5/0783

CPC classification number: A61K35/17 ,  A61K48/0091 ,  A61K2039/5156 ,  C12N5/0636 ,  C12N2501/23 ,  C12N2501/2302 ,  C12N2501/2306 ,  C12N2501/2307 ,  C12N2501/2315 ,  C12N2501/51 ,  C12N2501/515 ,  C12N2506/11 ,  C12N2510/00 ,  G01N33/56972 ,  G01N33/6863 ,  Y02A50/412 ,  Y02A50/58

Abstract: It is described in vitro methods for expanding, detecting or isolating rare populations of antigen specific memory T cells. It is also described an in vitro method for obtaining a genetically modified memory T cell population. Uses of cells so obtained are also disclosed.

Abstract translation: 描述用于扩增，检测或分离稀有抗原特异性记忆T细胞群的体外方法。 还描述了获得遗传修饰的记忆T细胞群体的体外方法。 还公开了如此获得的电池的用途。