公开(公告)号：US20210290646A1

公开(公告)日：2021-09-23

申请号：US17261928

申请日：2019-07-22

Applicant: OSPEDALE SAN RAFFAELE S.R.L. ,  FONDAZIONE CENTRO SAN RAFFAELE

Inventor： Attilio BONDANZA ,  Monica CASUCCI ,  Beatrice GRECO

IPC: A61K31/7004 ,  A61K35/17 ,  A61K39/395 ,  A61K31/145 ,  A61K31/437 ,  A61K31/7008 ,  A61K31/7072 ,  A61K31/407 ,  A61K45/06 ,  A61P35/00 ,  A61K38/17 ,  A61P35/02 ,  C12N5/0783

Abstract: The present invention relates to at least one glycosylation inhibitor for use in combination with CAR cell therapy. Preferably, the glycosylation inhibitor improves the therapeutic potential of the CAR cell therapy. The invention also relates to a pharmaceutical composition and to population or subpopulation of CAR cell that has been contacted with at least one glycosylation inhibitor.

公开(公告)号：US20250114386A1

公开(公告)日：2025-04-10

申请号：US18926669

申请日：2024-10-25

Applicant: OSPEDALE SAN RAFFAELE S.R.L. ,  FONDAZIONE CENTRO SAN RAFFAELE

Inventor： Attilio BONDANZA ,  Monica CASUCCI ,  Beatrice GRECO

IPC: A61K31/7004 ,  A61K31/145 ,  A61K31/407 ,  A61K31/437 ,  A61K31/7008 ,  A61K31/7072 ,  A61K38/17 ,  A61K39/00 ,  A61K39/395 ,  A61K45/06 ,  A61P35/00 ,  A61P35/02 ,  C12N5/0783

Abstract: The present invention relates to at least one glycosylation inhibitor for use in combination with CAR cell therapy. Preferably the glycosylation inhibitor improves the therapeutic potential of the CAR cell therapy. The invention also relates to pharmaceutical composition and to population or subpopulation of CAR cell that has been contacted with at least one glycosylation inhibitor.

公开(公告)号：US20230167407A1

公开(公告)日：2023-06-01

申请号：US17997377

申请日：2021-04-28

Applicant: OSPEDALE SAN RAFFAELE S.R.L.

Inventor： Barbara CAMISA ,  Monica CASUCCI ,  Silvia ARCANGELI ,  Claudia MEZZANOTTE ,  Laura FALCONE ,  Maria Chiara BONINI

IPC: C12N5/0783 ,  C12N15/86 ,  A61P35/00

CPC classification number: C12N5/0636 ,  C12N15/86 ,  A61P35/00 ,  C12N2501/2307 ,  C12N2501/2315 ,  C12N2740/15043

Abstract: The present invention refers to a method to produce a T cell with advantageous properties. The invention also refers to a T cell or an engineered T cell produced by the method and its use in therapy.