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公开(公告)号：US20250114386A1
公开(公告)日：2025-04-10
申请号：US18926669
申请日：2024-10-25
Inventor： Attilio BONDANZA , Monica CASUCCI , Beatrice GRECO
IPC: A61K31/7004 , A61K31/145 , A61K31/407 , A61K31/437 , A61K31/7008 , A61K31/7072 , A61K38/17 , A61K39/00 , A61K39/395 , A61K45/06 , A61P35/00 , A61P35/02 , C12N5/0783
Abstract: The present invention relates to at least one glycosylation inhibitor for use in combination with CAR cell therapy. Preferably the glycosylation inhibitor improves the therapeutic potential of the CAR cell therapy. The invention also relates to pharmaceutical composition and to population or subpopulation of CAR cell that has been contacted with at least one glycosylation inhibitor.
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公开(公告)号：US20210046159A1
公开(公告)日：2021-02-18
申请号：US16978897
申请日：2019-03-08
Inventor： Attilio BONDANZA , Barbara CAMISA , Margherita NORELLI
Abstract: The present invention relates to a IL-1 antagonist alone or in combination with other therapeutic agents and relative pharmaceutical compositions for use for the treatment and/or prevention of toxicity induced by a T cell therapy, wherein the T cell expresses at least one recombinant receptor.
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公开(公告)号：US20210290646A1
公开(公告)日：2021-09-23
申请号：US17261928
申请日：2019-07-22
Inventor： Attilio BONDANZA , Monica CASUCCI , Beatrice GRECO
IPC: A61K31/7004 , A61K35/17 , A61K39/395 , A61K31/145 , A61K31/437 , A61K31/7008 , A61K31/7072 , A61K31/407 , A61K45/06 , A61P35/00 , A61K38/17 , A61P35/02 , C12N5/0783
Abstract: The present invention relates to at least one glycosylation inhibitor for use in combination with CAR cell therapy. Preferably, the glycosylation inhibitor improves the therapeutic potential of the CAR cell therapy. The invention also relates to a pharmaceutical composition and to population or subpopulation of CAR cell that has been contacted with at least one glycosylation inhibitor.
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4.发明申请USE OF COMMON GAMMA CHAIN CYTOKINES FOR THE VISUALIZATION, ISOLATION AND GENETIC MODIFICATION OF MEMORY T LYMPHOCYTES 审中-公开使用通用链球菌进行可视化，分离和遗传修饰记忆体淋巴细胞公开(公告)号：US20150306142A1
公开(公告)日：2015-10-29
申请号：US14660484
申请日：2015-03-17
Applicant: OSPEDALE SAN RAFFAELE S.R.L.
Inventor： Maria Chiara BONINI , Attilio BONDANZA
IPC: A61K35/17 , C12N5/0783
CPC classification number: A61K35/17 , A61K48/0091 , A61K2039/5156 , C12N5/0636 , C12N2501/23 , C12N2501/2302 , C12N2501/2306 , C12N2501/2307 , C12N2501/2315 , C12N2501/51 , C12N2501/515 , C12N2506/11 , C12N2510/00 , G01N33/56972 , G01N33/6863 , Y02A50/412 , Y02A50/58
Abstract: It is described in vitro methods for expanding, detecting or isolating rare populations of antigen specific memory T cells. It is also described an in vitro method for obtaining a genetically modified memory T cell population. Uses of cells so obtained are also disclosed.
Abstract translation: 描述用于扩增，检测或分离稀有抗原特异性记忆T细胞群的体外方法。 还描述了获得遗传修饰的记忆T细胞群体的体外方法。 还公开了如此获得的电池的用途。
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