公开(公告)号：US20210046159A1

公开(公告)日：2021-02-18

申请号：US16978897

申请日：2019-03-08

Applicant: OSPEDALE SAN RAFFAELE S.R.L. ,  FONDAZIONE CENTRO SAN RAFFAELE

Inventor： Attilio BONDANZA ,  Barbara CAMISA ,  Margherita NORELLI

IPC: A61K38/20 ,  A61P39/00

Abstract: The present invention relates to a IL-1 antagonist alone or in combination with other therapeutic agents and relative pharmaceutical compositions for use for the treatment and/or prevention of toxicity induced by a T cell therapy, wherein the T cell expresses at least one recombinant receptor.

公开(公告)号：US20230167407A1

公开(公告)日：2023-06-01

申请号：US17997377

申请日：2021-04-28

Applicant: OSPEDALE SAN RAFFAELE S.R.L.

Inventor： Barbara CAMISA ,  Monica CASUCCI ,  Silvia ARCANGELI ,  Claudia MEZZANOTTE ,  Laura FALCONE ,  Maria Chiara BONINI

IPC: C12N5/0783 ,  C12N15/86 ,  A61P35/00

CPC classification number: C12N5/0636 ,  C12N15/86 ,  A61P35/00 ,  C12N2501/2307 ,  C12N2501/2315 ,  C12N2740/15043

Abstract: The present invention refers to a method to produce a T cell with advantageous properties. The invention also refers to a T cell or an engineered T cell produced by the method and its use in therapy.