公开(公告)号：US20200338131A1

公开(公告)日：2020-10-29

申请号：US16827708

申请日：2020-03-24

Applicant: Ospedale San Raffaele S.R.L. ,  Fondazione Telethon

Inventor： Luigi Naldini ,  Bernhard Rudolf Gentner ,  Erika Zonari ,  Francesco Boccalatte

IPC: A61K35/28 ,  C12N5/0789 ,  C12N15/86 ,  A61K48/00

Abstract: A method of preparing a therapeutic cell population for clinical use from a starting population of cells comprising haematopoietic stem cells, said method comprising separating a population of cells that substantially do not express CD38 but which express CD34 from the starting population of cells, and transducing the separated cell population with a vector to obtain the therapeutic cell population.

公开(公告)号：US20160256492A1

公开(公告)日：2016-09-08

申请号：US15031169

申请日：2014-10-24

Applicant: OSPEDALE SAN RAFFAELE S.R.L. ,  FONDAZIONE TELETHON

Inventor： Luigi Naldini ,  Bernhard Rudolf Gentner ,  Erika Zonari ,  Francesco Boccalatte

IPC: A61K35/28 ,  C12N15/86 ,  C12N7/00 ,  C12N5/0789

CPC classification number: A61K35/28 ,  A61K48/0091 ,  C12N5/0647 ,  C12N7/00 ,  C12N15/86 ,  C12N2510/00 ,  C12N2740/15043

Abstract: A method of preparing a therapeutic cell population for clinical use from a starting population of cells comprising haematopoietic stem cells, said method comprising separating a population of cells that substantially do not express CD38 but which express CD34 from the starting population of cells, and transducing the separated cell population with a vector to obtain the therapeutic cell population.

Abstract translation: 一种从包含造血干细胞的起始原始细胞群制备用于临床使用的治疗细胞群的方法，所述方法包括分离基本上不表达CD38但从起始细胞群体表达CD34的细胞群，并转导 用载体分离细胞群以获得治疗细胞群体。