公开(公告)号：US20230226304A1

公开(公告)日：2023-07-20

申请号：US17997715

申请日：2021-05-04

Applicant: OSPEDALE SAN RAFFAELE S.R.L. ,  POLITECNICO DI MILANO

Inventor： Giovanni LANDONI ,  Alberto ZANGRILLO ,  Filippo CONSOLO ,  Alberto REDAELLI ,  Gianfranco Beniamino FIORE ,  Alessandro CAIMI

IPC: A61M16/10 ,  A61M16/00 ,  A61M16/20

CPC classification number: A61M16/107 ,  A61M16/024 ,  A61M16/0066 ,  A61M16/205 ,  A61M16/209 ,  A61M2205/8206

Abstract: A stand-alone continuous positive airways pressure, CPAP, apparatus having a face-mask and a connected electro-mechanical device to supply air to the face-mask is disclosed. The electro-mechanical device includes a pneumatic channel for flowing air to be delivered to the face mask and a control unit for managing the air pressure of the air inside the pneumatic channel. The CPAP apparatus includes a turbine fan, located in the electro-mechanical device housing, connected to the control unit for pressurizing atmospheric air. The pneumatic channel includes an inlet portion located upstream of the turbine fan to receive atmospheric air, and an outlet portion located downstream of the turbine fan to deliver the pressurized air to the face-mask through an outlet opening. The pneumatic channel also longitudinally extends from the inlet portion to the outlet portion.

公开(公告)号：US20180105782A1

公开(公告)日：2018-04-19

申请号：US15567204

申请日：2016-04-28

Applicant: POLITECNICO DI MILANO ,  FONDAZIONE CARIPLO

Inventor： Alberto REDAELLI ,  Marco RASPONI ,  Paola OCCHETTA

IPC: C12M3/06 ,  C12M3/00 ,  C12M1/00 ,  C12M1/12 ,  C12M1/42

CPC classification number: C12M23/16 ,  C12M21/08 ,  C12M23/32 ,  C12M23/34 ,  C12M25/02 ,  C12M35/02 ,  C12M35/04

Abstract: A microfluidic device for controlled generation and/or culture and/or maturation of three-dimensional cells and/or tissue constructs that includes a culture chamber may include: a confinement apparatus configured to define at least one compartment configured to contain a cellular matrix and at least one compartment configured to contain a culture medium, the confinement apparatus being hydrophobic and pervious to the culture medium; and/or at least one counter element. The confinement apparatus and at least one counter element may be reciprocally mobile between resting and compression positions of the cellular matrix. A method for controlled generation and/or culture and/or maturation of three-dimensional cells and/or tissue constructs at a microscale may include: controlled compression of a cellular matrix for a predetermined period of time. The cellular matrix may be delimited by a confinement apparatus that is pervious to a culture medium.