公开(公告)号：US11802292B2

公开(公告)日：2023-10-31

申请号：US16959632

申请日：2019-01-04

Applicant: OTTAWA HOSPITAL RESEARCH INSTITUTE ,  TURNSTONE BIOLOGICS CORP.

Inventor： John C. Bell ,  Fabrice Le Boeuf ,  Michael S. Huh ,  Matthew Y. Tang ,  Adrian Pelin ,  Brian Andrew Keller ,  Caroline J. Breitbach ,  Michael F. Burgess ,  Steven H. Bernstein

IPC: C12N15/86 ,  A61K35/768 ,  C07K14/545 ,  C12N7/00 ,  C12N9/22

CPC classification number: C12N15/86 ,  A61K35/768 ,  C07K14/545 ,  C12N7/00 ,  C12N9/22 ,  C12N2710/24121 ,  C12N2710/24132 ,  C12Y306/01023

Abstract: The disclosure relates to modified orthopoxvirus vectors, as well as methods of using the same for the treatment of various cancers. The disclosure provides modified orthopoxvirus vectors that exhibit various beneficial therapeutic activities, including enhanced oncolytic activity, spread of infection, immune evasion, tumor persistence, capacity for incorporation of exogenous DNA sequences and safety. The viruses we have discovered are also amenable to large scale manufacturing protocols.

公开(公告)号：US20230022757A1

公开(公告)日：2023-01-26

申请号：US17694115

申请日：2022-03-14

Applicant: OTTAWA HOSPITAL RESEARCH INSTITUTE

Inventor： John C. Bell ,  Fabrice Le Boeuf ,  Michael S. Huh ,  Matthew Y. Tang ,  Brian Andrew Keller ,  Adrian Pelin

IPC: C12N15/86 ,  A61P31/20 ,  A61P35/00 ,  A61K39/285

Abstract: The disclosure relates to modified vaccinia virus vectors derived from the Copenhagen strain of vaccinia virus, as well as methods of using the same for the treatment of various cancers. The disclosure provides modified Copenhagen-derived vaccinia virus vectors that exhibit various beneficial therapeutic activities, including enhanced oncolytic activity, spread of infection, immune evasion, tumor persistence, capacity for incorporation of exogenous DNA sequences, amenability for large scale manufacturing, and safety.

公开(公告)号：US20240229069A9

公开(公告)日：2024-07-11

申请号：US18461241

申请日：2023-09-05

Applicant: OTTAWA HOSPITAL RESEARCH INSTITUTE ,  TURNSTONE BIOLOGICS CORP.

Inventor： John C. Bell ,  Fabrice Le Boeuf ,  Michael S. Huh ,  Matthew Y. Tang ,  Adrian Pelin ,  Brian Andrew Keller ,  Caroline J. Breitbach ,  Michael F. Burgess ,  Steven H. Bernstein

IPC: C12N15/86 ,  A61K35/768 ,  C07K14/545 ,  C12N7/00 ,  C12N9/22

CPC classification number: C12N15/86 ,  A61K35/768 ,  C07K14/545 ,  C12N7/00 ,  C12N9/22 ,  C12N2710/24121 ,  C12N2710/24132 ,  C12Y306/01023

Abstract: The disclosure relates to modified orthopoxvirus vectors, as well as methods of using the same for the treatment of various cancers. The disclosure provides modified orthopoxvirus vectors that exhibit various beneficial therapeutic activities, including enhanced oncolytic activity, spread of infection, immune evasion, tumor persistence, capacity for incorporation of exogenous DNA sequences and safety. The viruses we have discovered are also amenable to large scale manufacturing protocols.

公开(公告)号：US20240132913A1

公开(公告)日：2024-04-25

申请号：US18461241

申请日：2023-09-04

Applicant: OTTAWA HOSPITAL RESEARCH INSTITUTE ,  TURNSTONE BIOLOGICS CORP.

Inventor： John C. Bell ,  Fabrice Le Boeuf ,  Michael S. Huh ,  Matthew Y. Tang ,  Adrian Pelin ,  Brian Andrew Keller ,  Caroline J. Breitbach ,  Michael F. Burgess ,  Steven H. Bernstein

IPC: C12N15/86 ,  A61K35/768 ,  C07K14/545 ,  C12N7/00 ,  C12N9/22

CPC classification number: C12N15/86 ,  A61K35/768 ,  C07K14/545 ,  C12N7/00 ,  C12N9/22 ,  C12N2710/24121 ,  C12N2710/24132 ,  C12Y306/01023

Abstract: The disclosure relates to modified orthopoxvirus vectors, as well as methods of using the same for the treatment of various cancers. The disclosure provides modified orthopoxvirus vectors that exhibit various beneficial therapeutic activities, including enhanced oncolytic activity, spread of infection, immune evasion, tumor persistence, capacity for incorporation of exogenous DNA sequences and safety. The viruses we have discovered are also amenable to large scale manufacturing protocols.