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    Biochemical analysis instrument
    3.
    发明授权
    Biochemical analysis instrument 有权

    公开(公告)号：US09651519B2

    公开(公告)日：2017-05-16

    申请号：US14812510

    申请日：2015-07-29

    申请人： OXFORD NANOPORE TECHNOLOGIES LIMITED

    发明人： Clive Gavin Brown ,  James Peter Willcocks

    IPC分类号： G01N15/06 ,  G01N33/00 ,  G01N33/48 ,  G01N27/447 ,  G01N33/487 ,  C12Q1/68

    CPC分类号： G01N27/44756 ,  C12Q1/6869 ,  G01N33/48721

    摘要： An analysis instrument comprises plural modules connected together over a data network, each module comprising an analysis apparatus operable to perform biochemical analysis of a sample. Each module comprises a control unit that controls the operation of the analysis apparatus. The control units are addressable to select an arbitrary number of modules to operate as a cluster for performing a common biochemical analysis. The control units communicate over the data network, repeatedly during the performance of the common biochemical analysis, to determine the operation of the analysis apparatus of each module required to meet the global performance targets, on the basis of measures of performance derived from the output data produced by the modules. The arrangement of the instrument as modules interacting in this manner provides a scalable analysis instrument.

    FORMATION OF ARRAY OF MEMBRANES AND APPARATUS THEREFOR
    4.
    发明申请
    FORMATION OF ARRAY OF MEMBRANES AND APPARATUS THEREFOR 审中-公开
    形成膜片及其装置

    公开(公告)号：US20150265994A1

    公开(公告)日：2015-09-24

    申请号：US14438705

    申请日：2013-10-23

    申请人： OXFORD NANOPORE TECHNOLOGIES LIMITED

    发明人： Jason Robert Hyde ,  Pedro Miguel Ortiz Bahamon ,  Clive Gavin Brown ,  Andrew John Heron ,  Paul Raymond Mackett

    IPC分类号： B01J19/00 ,  G01N33/573 ,  C12Q1/68

    摘要： An array of membranes comprising amphipathic molecules is formed using an apparatus comprising a support defining an array of compartments. Volumes comprising polar medium are provided within respective compartments and a layer comprising apolar medium is provided extending across the openings with the volumes. Polar medium is flowed across the support to displace apolar medium and form a layer in contact with the volumes, forming membranes comprising amphipathic molecules at the interfaces. In one construction of the apparatus, the support that comprises partitions which comprise inner portions and outer portions. The inner portions define inner recesses without gaps therebetween that are capable of constraining the volumes comprising polar medium contained in neighbouring inner recesses from contacting each other. The outer portions extend outwardly from the inner portions and have gaps allowing the flow of an apolar medium across the substrate.

    摘要翻译： 使用包括限定隔室阵列的支架的装置形成包含两亲分子的膜阵列。 包含极性介质的体积被设置在相应的隔室内，并且提供包括非极性介质的层，其跨越具有体积的开口延伸。 极性介质流过载体以置换非极性介质并形成与体积接触的层，在界面处形成包含两亲性分子的膜。 在该装置的一个结构中，支撑件包括包括内部部分和外部部分的隔板。 内部部分限定内部凹部，其之间没有间隙，其能够约束包含相邻内凹部中的极性介质的体积彼此接触。 外部部分从内部部分向外延伸并且具有允许非极性介质流过基板的间隙。

    DROPLET INTERFACES
    8.
    发明申请
    DROPLET INTERFACES 有权
    DROPLET接口

    公开(公告)号：US20150285781A1

    公开(公告)日：2015-10-08

    申请号：US14438670

    申请日：2013-10-23

    申请人： OXFORD NANOPORE TECHNOLOGIES LIMITED

    发明人： Andrew John Heron ,  Jason Robert Hyde ,  Clive Gavin Brown

    IPC分类号： G01N33/487 ,  B01D71/70 ,  B01D67/00

    CPC分类号： G01N33/48721 ,  B01D67/0023 ,  B01D69/122 ,  B01D71/26 ,  B01D71/32 ,  B01D71/58 ,  B01D71/70 ,  B01D71/80 ,  B01D2323/35 ,  B01D2325/36 ,  B01D2325/38 ,  C12Q1/6869 ,  G01N33/50 ,  Y10T436/145555 ,  C12Q2565/631

    摘要： The invention provides a method of forming a membrane between a first volume of polar medium and a second volume of polar medium, which method comprises: (a) providing a first volume comprising polar medium and a second volume comprising polar medium which are separated from one another by an apolar medium, wherein at least one of said first and second volumes comprises a layer comprising amphipathic molecules, at the interface between the polar medium and the apolar medium, wherein each of the amphipathic molecules comprises a first outer hydrophilic group, a hydrophobic core group, and a second outer hydrophilic group, wherein each of the first and second outer hydrophilic groups is linked to the hydrophobic core group; and (b) causing the first and second volumes to come into contact with one another to form a membrane comprising said amphipathic molecules between the first and second volumes. The invention also provides a system comprising a membrane between a first volume of a polar medium; and a second volume of a polar medium, which membrane comprises the amphipathic molecules, and wherein the first volume of polar medium is within an apolar medium.

    摘要翻译： 本发明提供了一种在第一体积的极性介质和第二体积的极性介质之间形成膜的方法，该方法包括：（a）提供包含极性介质的第一体积和包含极性介质的第二体积，所述第二体积与极性介质分离， 另一个通过非极性介质，其中所述第一和第二体积中的至少一个包含在极性介质和非极性介质之间的界面处的包含两亲性分子的层，其中每个两亲性分子包含第一外部亲水基团，疏水性 核心基团和第二外部亲水基团，其中第一和第二外部亲水基团中的每一个连接到疏水性核心基团; 和（b）使第一和第二体积彼此接触以形成包含第一和第二体积之间的所述两亲分子的膜。 本发明还提供一种系统，其包括在第一体积的极性介质之间的膜; 和第二体积的极性介质，所述膜包含两亲性分子，并且其中所述第一体积的极性介质在非极性介质内。