公开(公告)号：US20150177237A1

公开(公告)日：2015-06-25

申请号：US14378929

申请日：2013-02-14

申请人： OXFORD NANOPORE TECHNOLOGIES LIMITED

发明人： Daniel John Turner ,  Daniel George Fordham ,  Roger Charles Gill ,  Clive Gavin Brown ,  Stuart Reid ,  James Anthony Clarke ,  James White

IPC分类号： G01N33/543 ,  C12N15/115

摘要： The invention relates to a new method of determining in a sample the presence or absence of one or more analyte members of a group of two or more analytes. The invention therefore relates to a multiplex assay for determining the presence or absence of each analyte in a group of multiple analytes. The assay uses aptamers and transmembrane pores.

摘要翻译： 本发明涉及一种在样品中测定两种或更多种分析物组的一种或多种分析物成分的存在或不存在的新方法。 因此，本发明涉及用于确定一组多种分析物中每种分析物的存在或不存在的多重测定。 该测定使用适体和跨膜孔。

公开(公告)号：US10739341B2

公开(公告)日：2020-08-11

申请号：US14378929

申请日：2013-02-14

申请人： OXFORD NANOPORE TECHNOLOGIES LIMITED

发明人： Daniel John Turner ,  Daniel George Fordham ,  Roger Charles Gill ,  Clive Gavin Brown ,  Stuart Reid ,  James Anthony Clarke ,  James White

IPC分类号： G01N33/00 ,  G01N33/543 ,  G01N33/53 ,  C12N15/115 ,  C07H21/04

摘要： The invention relates to a new method of determining in a sample the presence or absence of one or more analyte members of a group of two or more analytes. The invention therefore relates to a multiplex assay for determining the presence or absence of each analyte in a group of multiple analytes. The assay uses aptamers and transmembrane pores.

公开(公告)号：US20210018500A1

公开(公告)日：2021-01-21

申请号：US16916305

申请日：2020-06-30

申请人： Oxford Nanopore Technologies Limited

发明人： Daniel John Turner ,  Daniel George Fordham ,  Roger Charles Gill ,  Clive Gavin Brown ,  Stuart Reid ,  James Anthony Clarke ,  James White

IPC分类号： G01N33/543 ,  G01N33/53 ,  C12N15/115

摘要： The invention relates to a new method of determining in a sample the presence or absence of one or more analyte members of a group of two or more analytes. The invention therefore relates to a multiplex assay for determining the presence or absence of each analyte in a group of multiple analytes. The assay uses aptamers and transmembrane pores.

公开(公告)号：US20150057948A1

公开(公告)日：2015-02-26

申请号：US14379242

申请日：2013-02-18

申请人： OXFORD NANOPORE TECHNOLOGIES LIMITED

发明人： Stuart Reid ,  James Anthony Clarke ,  James White ,  Gavin Harper

IPC分类号： G01N33/487 ,  G01N33/68 ,  G01N27/02

CPC分类号： G01N33/48792 ,  B82Y15/00 ,  C12Q1/6858 ,  C12Q1/6869 ,  G01N27/02 ,  G01N33/48721 ,  G01N33/6803 ,  G01N33/6875 ,  G16B30/00 ,  C12Q2537/165 ,  C12Q2565/631

摘要： A time-ordered series of measurements of a polymer made during translocation of the polymer through a nanopore are analysed. The measurements are dependent on the identity of k-mers in the nanopore, a k-mer being k polymer units of the polymer, where k is a positive integer. The method involves deriving, from the series of measurements, a feature vector of time-ordered features representing characteristics of the measurements; and determining similarity between the derived feature vector and at least one other feature vector.

摘要翻译： 分析了在聚合物通过纳米孔的位移期间制备的聚合物的时间有序的一系列测量。 测量取决于纳米孔中的k-mers的同一性，k-mer是聚合物的聚合物单元，其中k是正整数。 该方法包括从一系列测量中导出表示测量特征的时间有序特征的特征向量; 以及确定所导出的特征向量与至少一个其他特征向量之间的相似度。