公开(公告)号：US11058725B2

公开(公告)日：2021-07-13

申请号：US17017670

申请日：2020-09-10

申请人： Obsidian Therapeutics, Inc.

发明人： Kutlu Goksu Elpek ,  Dhruv Kam Sethi ,  Meghan C. Langley ,  Tucker Read Ezell ,  Dexue Sun ,  Jennifer Leah Gori ,  Geetha Hanna Mylvaganam ,  Michelle Ols ,  Michelle Fleury ,  Celeste Richardson ,  James A. Storer ,  Vipin Suri ,  Shyamsundar Subramanian ,  Colleen Foley ,  Molly Reed Perkins ,  Jeremy Hatem Tchaicha ,  Scott Francis Heller

IPC分类号： A61K35/17 ,  C12N15/86 ,  C07K14/54 ,  A61K31/433 ,  C12N9/88 ,  C12N15/867 ,  C12N15/864 ,  C12N15/869 ,  C12N15/861

摘要： The present disclosure provides drug responsive domains derived from human carbonic anhydrase 2 that can modulate protein stability for human interleukin 15 (IL15) payloads, as well as compositions and methods of use thereof.