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公开(公告)号：US12104178B2
公开(公告)日：2024-10-01
申请号：US17646212
申请日：2021-12-28
发明人： Vipin Suri , Dan Jun Li , Dexue Sun , Byron Delabarre , Vijaya Balakrishnan , Brian Dolinski , Mara Christine Inniss , Grace Y. Olinger
IPC分类号： A61K35/17 , C07K14/54 , C07K14/705 , C07K14/715 , C12N9/06 , C12N15/85 , C12N15/86
CPC分类号： C12N9/003 , A61K35/17 , C07K14/5434 , C07K14/5443 , C07K14/70503 , C07K14/7155 , C12N15/85 , C12Y105/01003 , C07K2319/30 , C07K2319/33
摘要： The present invention is related to compositions and methods for the regulated and controlled expression of proteins.
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公开(公告)号：US20230056856A1
公开(公告)日：2023-02-23
申请号：US17791091
申请日：2021-01-08
摘要： The present disclosure provides compositions and methods related to transcription factor systems. Such systems provide for modular and tunable protein expression driven by regulated transcriptional activity.
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公开(公告)号：US20230026259A1
公开(公告)日：2023-01-26
申请号：US17436892
申请日：2020-03-06
发明人： Vipin SURI , Celeste RICHARDSON , Brian DOLINSKI , Abhishek KULKARNI , Mara Christine Inniss , Dexue SUN , Elizabeth Jane WEISMAN , Grace Y. Olinger , Scott Francis HELLER , Jennifer Leah GORI , Michelle Lynn OLS , Kutlu Goksu ELPEK , Tucker Read EZELL , Michael SCHEBESTA , Michelle Lois FLEURY , Dhruv Kam SETHI
IPC分类号： C12N9/88 , A61K39/00 , C07K14/705
摘要： The present disclosure provides regulatable biocircuit systems. Such systems provide modular and tunable protein expression systems in support of the discovery and development of therapeutic modalities. In particular, the present application is directed to fusion proteins comprising a fragment of human human carbonic anhydrase 2 and a chimeric antigen receptor (CAR). The activity of the destabilizing domain can be regulated by externally administered agents.
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公开(公告)号：US20220348937A1
公开(公告)日：2022-11-03
申请号：US17753505
申请日：2020-09-04
摘要： The present disclosure is related to compositions and methods for the regulated and controlled expression of proteins.
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公开(公告)号：US11446398B2
公开(公告)日：2022-09-20
申请号：US16092829
申请日：2017-04-11
发明人： Peter Barrett , Michael N. Gladstone , Tariq A. Kassum , Vipin Suri , Dan Jun Li , Dexue Sun , Brian Dolinski
IPC分类号： A61K38/52 , C12N9/90 , A61K48/00 , C07K16/28 , C07K14/00 , A61P3/08 , A61K35/17 , C07K14/195 , C07K14/54 , C07K14/605 , C07K14/725 , C07K14/705 , C12N5/0789 , C12N9/22 , C12N9/00 , C12N15/11 , A61K38/00
摘要： The present invention provides regulatable biocircuit systems. Such systems provide modular and tunable protein expression systems in support of the discovery and development of therapeutic modalities.
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公开(公告)号：US20220213449A1
公开(公告)日：2022-07-07
申请号：US17646212
申请日：2021-12-28
发明人： Vipin SURI , Dan Jun LI , Dexue SUN , Byron DELABARRE , Vijaya BALAKRISHNAN , Brian DOLINSKI , Mara Christine INNISS , Grace Y. OLINGER
IPC分类号： C12N9/06 , C07K14/54 , C07K14/715 , C12N15/85 , A61K35/17 , C07K14/705
摘要： The present invention is related to compositions and methods for the regulated and controlled expression of proteins.
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公开(公告)号：US11241485B2
公开(公告)日：2022-02-08
申请号：US16621593
申请日：2018-06-12
发明人： Vipin Suri , Byron Delabarre , Michael N. Gladstone , Celeste Richardson , Brian Dolinski , Abhishek Kulkarni , Mara Christine Inniss , Dexue Sun , Dan Jun Li , Grace Y. Olinger , Scott Francis Heller
IPC分类号： A61K38/46 , A61P35/00 , A61K31/4985 , A61K35/17 , A61K38/17 , A61K38/20 , A61K39/395 , C07K14/54 , C07K14/725 , C07K14/705 , C07K14/715 , C07K16/28 , C12N9/16 , A61K39/00 , A61P37/04 , C07K19/00
摘要： The present invention relates to compositions and methods for the regulated and controlled expression of proteins. Methods for inducing anti-cancer immune responses in a subject are also provided.
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公开(公告)号：US20210386788A1
公开(公告)日：2021-12-16
申请号：US17288373
申请日：2019-10-23
发明人： Vipin SURI , Dexue SUN , Michelle Lynn OLS , Scott Francis HELLER , Dan Jun LI , Celeste RICHARDSON , Mara Christine INNISS , Jennifer Leah GORI , Benjamin J. PRIMACK , Abhishek KULKARNI , Brian DOLINSKI , Tucker Read EZELL , Michael SCHEBESTA , James A. STORER , Kutlu Goksu ELPEK
IPC分类号： A61K35/28 , A61K31/4535 , A61K31/55 , C07K14/705 , C07K16/28 , C07K14/725 , C07K14/54 , C07K14/715 , A61P35/00
摘要： The present disclosure is related to compositions and methods for the regulated and controlled expression of proteins.
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公开(公告)号：US20220259284A1
公开(公告)日：2022-08-18
申请号：US17596281
申请日：2020-06-12
IPC分类号： C07K14/705 , C07K14/725 , A61K45/06 , C12N9/88 , C12N15/86
摘要： The present disclosure provides regulatable biocircuit systems. Such systems provide modular and tunable protein expression systems in support of the discovery and development of therapeutic modalities.
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公开(公告)号：US20240075064A1
公开(公告)日：2024-03-07
申请号：US18261761
申请日：2022-01-18
发明人： Kutlu Goksu Elpek , Celeste Richardson , Michelle Lois Fleury , James Alex Storer , Shyamsundar Subramanian , Mithun Khattar
IPC分类号： A61K35/17 , A61K39/00 , A61P35/00 , C07K14/54 , C12N5/0783
CPC分类号： A61K35/17 , A61K39/4611 , A61K39/46444 , A61P35/00 , C07K14/5443 , C12N5/0636
摘要： The present disclosure provides compositions and methods for expanding T cells or tumor infiltrating lymphocytes (TILs) in vitro. K562 feeder cells engineered to express a costimulatory molecule (e.g., 41BB ligand (41BBL)) and either interleukin 21 (IL21) or interleukin 7 (IL7) can be used in a rapid expansion protocol (REP) step to expand the T cells or TILs. Thus, provided herein is a culture comprising T-cells or TILs and modified K562 feeder cells. The T cells can be modified to express a chimeric antigen receptor (CAR) or a T cell receptor (TCR) or the TILs can be modified to express membrane-bound IL15 (mbIL15). The T cells or TILs can be expanded in vitro using aREP without the use of exogenous interleukin 2 (IL2), and the expanded cells can be used in adoptive cell therapy for treatment of cancer without concomitant use of an exogenous cytokine such as IL2.
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