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    High throughput monitoring chamber for testing drug effects on repolarization and conduction
    1.
    发明申请
    High throughput monitoring chamber for testing drug effects on repolarization and conduction 审中-公开
    高通量监测室，用于测试药物对复极和传导的影响

    公开(公告)号：US20050009006A1

    公开(公告)日：2005-01-13

    申请号：US10841266

    申请日：2004-05-07

    申请人： Ofer Binah ,  Ira Cohen ,  Richard Robinson ,  Michael Rosen

    发明人： Ofer Binah ,  Ira Cohen ,  Richard Robinson ,  Michael Rosen

    IPC分类号： G01N33/50 ,  C12Q1/00 ,  C12N5/06

    CPC分类号： G01N33/5061 ,  G01N33/5008 ,  G01N33/502 ,  G01N33/5073

    摘要： The invention provides a method for determining the effects of an agent on repolarization of cells in vitro, comprising stimulating the cells with an energy source and under conditions sufficient and for a time sufficient to depolarize the cells, measuring the QT interval of the electrical signals output by the cells in response to the stimulating step, contacting the cells with an agent, re-stimulating the cells with the same energy source and under the same conditions as the first stimulating step and for a time sufficient to depolarize the cells, measuring the QT interval of the electrical signals output by the cells in response to the second stimulating step, and comparing the results of the measuring taken after the first and second stimulating steps to determine whether the agent affects repolarization of cells. The present invention also provides a method for determining the effects of an agent on conduction of cells in vitro.

    摘要翻译： 本发明提供了一种用于确定试剂对体外细胞复极化的影响的方法，包括用能量源刺激细胞并在足以使足以使细胞去极化的时间的条件下测量电信号输出的QT间隔 通过响应于刺激步骤的细胞，使细胞与试剂接触，用与第一刺激步骤相同的能量源和相同的条件再刺激细胞并持续足以使细胞去极化的时间，测量QT 响应于第二刺激步骤由细胞输出的电信号的间隔，以及比较在第一和第二刺激步骤之后测量的结果以确定试剂是否影响细胞的复极化。 本发明还提供了一种用于测定试剂对体外细胞传导的影响的方法。